神经体液因素在胆结石形成中的作用机制

Mechanisms underlying the roles of nervous and humoral factors in the pathogenesis of gallstones

胆结石是常见病,患病率在10%左右.近年研究显示,神经体液因素参与胆结石的发病.本文将分别论述副交感神经、交感神经、非肾上腺能非胆碱能神经、胆囊收缩素、胃泌素、蛙皮素、胃泌素释放肽、胃动素、血管活性肠肽、生长抑素、胰多肽、P物质、胰泌素、神经减压素、阿片肽、一氧化氮、雌激素、甲状腺素及瘦素参与胆结石形成的作用机制.

Gallstone disease is a common disorder with an incidence rate of about 10%.Recent research has revealed that nervous and humoral factors are involved in the pathogenesis of gallstone disease.This article focuses on the mechanisms underlying the roles of parasympathetic nerve,sympathetic nerve,non-adrenergic non-cholinergic nerve,cholecystokinin,gastrin,bombesin,gastrin-releasing peptide,motilin,vasoactive intestinal polypeptide,somatostatin,pancreatic polypeptide,substance P,secretin,neurotensin,opioid peptide,nitric oxide,estrogen,thyroxine,and leptin in the pathogenesis of gallstones.