期刊文献+

晚期胰腺癌的化疗进展 被引量:5

Advances in chemotherapy of advanced pancreatic cancer
下载PDF
导出
摘要 胰腺癌在诊断时多数为晚期,采用以化疗为主的综合治疗.吉西他滨仍然是化疗的标准用药,吉西他滨为基础的联合治疗取得了一定的疗效,靶向药物的应用使优势人群的疗效进一步提高.本文就多种治疗策略在晚期胰腺癌中的进展作一总结. Most patients with pancreatic cancer are diagnosed at advanced stage and have to undergo chemotherapy-based comprehensive therapy.Gemcitabine is still the standard chemotherapeutic drug for pancreatic cancer.Although gemcitabine-based combination therapy has certain curative effects on pancreatic cancer,combined application of targeted drugs can enhance the efficacy of chemotherapy in superiority crowd.This paper reviews the recent advances in chemotherapy of advanced pancreatic cancer.
作者 徐玲 刘云鹏
出处 《世界华人消化杂志》 CAS 北大核心 2010年第25期2685-2689,共5页 World Chinese Journal of Digestology
基金 国家自然科学基金资助项目 No.30770993~~
关键词 胰腺癌 化疗 放疗 靶向治疗 Pancreatic cancer Chemotherapy Radiotherapy Targeted therapy
  • 相关文献

参考文献31

  • 1Fung MC,Ishiguro H,Takayama S,Morizane T,Adachi S,Sakata T.Survival benefit of chemotherapy treatment in advanced pancreatic cancer: A meta-analysis.Proc ASCO,annual meeting 2003: a1155.
  • 2Burris HA 3rd,Moore MJ,Andersen J,Green MR,Rothenberg ML,Modiano MR,Cripps MC,Portenoy RK,Storniolo AM, Tarassoff P,Nelson R,Dorr FA,Stephens CD,Von Hoff DD.Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.J Clin Oncol 1997; 15: 2403-2413.
  • 3Heinemann V,Quietzsch D,Gieseler F,Gonnermann M,Schonekas H,Rost A,Neuhaus H,Haag C,Stoffregen C,Clemens M; Klinikum Grosshadern.A phase III trial comparing gemcitabine plus cisplatin vs.gemcitabine alone in advanced pancreatic carcinoma.Proc ASCO,annual meeting 2003: a1003.
  • 4Louvet C,Hincke A,Labianca R,Heinemann V.Increased survival using platinum analog combined with gemcitabine as compared to gemcitabine single agent in advanced pancreatic cancer (APC): Pooled analysis of two randomised trials,the GERCOR/GISCAD Intergroup Study and a German Multicenter Study.Proc ASCO,annual meeting 2006: a4003.
  • 5Poplin E,Feng Y,Berlin J,Rothenberg ML,Hochster H,Mitchell E,Alberts S,O'Dwyer P,Haller D,Catalano P,Cella D, Benson AB 3rd.Phase III,randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group.J Clin Oncol 2009; 27: 3778-3785.
  • 6Riess H,Helm A,Niedergethmann M,Schmidt-Wolf I,Moik M,Hammer C,Zippel K,Weigang-K?hler K,Stauch M,Oettle H, Deutsche Krebsgesellschaft.A Randomised,Prospective,Multicenter,Phase III Trial of Gemcitabine,5-Fluorouracil (5-FU), Folinic Acid vs.Gemcitabine alone in Patients with Advanced Pancreatic Cancer.Proc ASCO,annual meeting 2005: a4009.
  • 7Herrmann R,Bodoky G,Ruhstaller T,Glimelius B,Bajetta E,Schüller J,Saletti P,Bauer J,Figer A,Pestalozzi B,K?hne CH, Mingrone W,Stemmer SM,Tàmas K,Kornek GV,Koeberle D,Cina S,Bernhard J,Dietrich D,Scheithauer W.Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized,multicenter,phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group.J Clin Oncol 2007; 25: 2212-2217.
  • 8Cunningham D,Chau I,Stocken DD,Valle JW,Smith D,Steward W,Harper PG,Dunn J,Tudur-Smith C,West J,Falk S, Crellin A,Adab F,Thompson J,Leonard P,Ostrowski J,Eatock M,Scheithauer W,Herrmann R,Neoptolemos JP.Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer.J Clin Oncol 2009; 27: 5513-5518.
  • 9Heinemann V,Boeck S,Hinke A,Labianca R,Louvet C.Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer.BMC Cancer 2008; 8: 82.
  • 10Xie DR,Yang Q,Chen DL,Jiang ZM,Bi ZF,Ma W,Zhang YD.Gemcitabine-based cytotoxic doublets chemotherapy for advanced pancreatic cancer: updated subgroup meta-analyses of overall survival.Jpn J Clin Oncol 2010; 40: 432-441.

同被引文献68

  • 1马霄虹,赵心明,张红梅,欧阳汉,曾蒙苏,宋彬,郭宁,胡敏霞,张瑾,叶枫,胡毅,屈东,周纯武.CT与MRI诊断胰腺癌方案优选的多中心研究[J].中华临床医师杂志(电子版),2011,5(21):6260-6265. 被引量:7
  • 2金斗镇.中医对胰腺癌的认识和治疗方法[J].黑龙江中医药,2006,35(5):57-59. 被引量:11
  • 3龚继芳,张晓东,李洁,邸立军,金懋林,沈琳.吉西他滨为基础的化疗方案治疗进展期胰腺癌的临床研究[J].癌症,2007,26(8):890-894. 被引量:15
  • 4Vincent A,Herman J,Schulick R,Hruban RH,Gog-gins M.Pancreatic cancer.Lancet2011;378:607-620.
  • 5Neoptolemos JP,Dunn JA,Stocken DD,Almond J,Link K,Beger H,Bassi C,Falconi M,Pederzoli P,Dervenis C,Fernandez-Cruz L,Lacaine F,Pap A,Spooner D,Kerr DJ,Friess H,Büchler MW.Adju-vant chemoradiotherapy and chemotherapy in re-sectable pancreatic cancer:a randomised controlled trial.Lancet2001;358:1576-1585.
  • 6Benson AB,Schrag D,Somerfield MR,Cohen AM,Figueredo AT,Flynn PJ,Krzyzanowska MK,Maroun J,McAllister P,Van Cutsem E,Brouwers M,Charette M,Haller DG.American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer.J Clin Oncol2004;22:3408-3419.
  • 7Kalser MH,Ellenberg SS.Pancreatic cancer.Adju-vant combined radiation and chemotherapy follow-ing curative resection.Arch Surg1985;120:899-903.
  • 8Yeo CJ,Abrams RA,Grochow LB,Sohn TA,Ord SE,Hruban RH,Zahurak ML,Dooley WC,Coleman J,Sauter PK,Pitt HA,Lillemoe KD,Cameron JL.Pancreaticoduodenectomy for pancreatic adeno-carcinoma:postoperative adjuvant chemoradiation improves survival.A prospective,single-institution experience.Ann Surg1997;225:621-633;discussion633-636.
  • 9Klinkenbijl JH,Jeekel J,Sahmoud T,van Pel R,Couvreur ML,Veenhof CH,Arnaud JP,Gonzalez DG,de Wit LT,Hennipman A,Wils J.Adjuvant radiotherapy and5-fluorouracil after curative resec-tion of cancer of the pancreas and periampullary region:phase III trial of the EORTC gastrointestinal tract cancer cooperative group.Ann Surg1999;230:776-782;discussion782-784.
  • 10Neoptolemos JP,Stocken DD,Tudur Smith C,BassiC,Ghaneh P,Owen E,Moore M,Padbury R,Doi R,Smith D,Büchler MW.Adjuvant5-fluorouracil and folinic acid vs observation for pancreatic cancer:composite data from the ESPAC-1and-3(v1)trials.Br J Cancer2009;100:246-250.

引证文献5

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部