摘要
HER-2/neu基因,也称CerbB-2,为人类表皮生长因子受体(EGFR)家族的第2个成员.许多研究认为胃癌组织中存在HER-2基因扩增和/或蛋白的过表达.针对HER-2基因的免疫治疗可能成为晚期胃癌患者新的重要治疗选择,因此,胃癌组织中HER-2基因状态的检测就显得非常重要.本文就胃癌HER-2基因检测方法及其靶向治疗的研究现状进行综述.
HER-2/neu, also known as cerbB-2, is the second member of the human epidermal growth factor receptor （EGFR） family. Some studies have shown that HER-2 gene amplification and/or protein overexpression occur in gastric carcinoma. HER-2 gene immunotherapy may become an important new option for patients with advanced gastric cancer. Therefore, the detection of HER-2 gene status becomes very important in these patients. This paper gives an overview of the recent advances in the detection of HER-2 gene status and HER-2-targeted therapy in gastric cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第26期2785-2789,共5页
World Chinese Journal of Digestology
关键词
胃癌
HER-2基因
靶向治疗
检测方法
基因扩增
免疫组织化学
Gastric carcer
HER-2 gene
Targeted therapy
Detection Method
Gene amplification
Immunohistochemistry
