摘要
目的:观察三维适形放射治疗联合扩张术在治疗晚期食管癌中的疗效.方法:将中国人民解放军174医院行三维适形放射治疗的36例食管癌患者随机分为两组,A组10例仅行放射治疗;B组26例行放射治疗联合扩张术.分别观察1、2年生存率、并发症发生率及吞咽困难分级情况.结果:A组1、2年生存率分别为33.23%、29.16%;并发症发生率50.00%;治疗后吞咽困难Stooler分级0级0例、1级1例、2级2例、3级1例、4级6例;B组1、2年生存率分别为34.88%、30.91%;并发症发生率42.31%;治疗后吞咽困难Stooler分级0级1例、1级2例、2级4例、3级6例、4级13例;1、2年生存率、并发症发生率两者无明显差别,吞咽困难改善程度上,B组疗效均优于A组,差异有统计学意义(χ2=5.11,P<0.05).结论:三维适形放射治疗联合扩张术治疗晚期食管癌吞咽困难疗效明显.
AIM: To evaluate the efficacy of three-dimen- sional conformal radiotherapy in combination with esophageal dilatation in the treatment of advanced esophageal carcinoma. METHODS: Thirty-six patients with advanced esophageal carcinoma who underwent three-dimensional conformal radiotherapy were randomly divided into two groups: patients receiving only radiotherapy (radiotherapy group, n = 10) and those receiving radiotherapy in combination with esophageal dilation (combination treatment group, n = 26). The 1- and 2-years survival rates, the incidence of complications, and dysphagia grade in these patients were then determined. RESULTS: There are no significant differencesin the 1- and 2-year survival rates and the incidence of complications between the radiotherapy group and the combination treatment group (1-year survival rate: 33.23% vs 34.88%; 2-year survival rate: 29.16% vs 30.91%; incidence of complications: 50.00% vs 42.31%; all P 0.05). The numbers of patients with Stooler grades 0, 1, 2, 3 and 4 dysphagia in the radiotherapy group are 0, 1, 2, 1 and 6, and the corresponding figures in the combination treatment group are 1, 2, 4, 6 and 13, respectively. Dysphagia improvement was more significant in the combination treatment group than in the radiotherapy group (χ2 = 5.11, P 0.05). CONCLUSION: Three-dimensional conformal radiotherapy in combination with esophageal dilatation is superior to radiotherapy alone in improving dysphagia in patients with advanced esophageal carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第26期2809-2811,共3页
World Chinese Journal of Digestology
关键词
食管癌
三维适形放射治疗
扩张术
Esophageal carcinoma
Three-dimensional conformal radiotherapy
Esophageal dilata- tion