中药复方旋复代赭汤合左金丸干预胃食管反流病的疗效

Efficacy of Xuanfudaizhe Decoction in combination with Zuojin Pill in the treatment of gastroesophageal reflux disease

目的:探讨旋复代赭汤合左金丸干预胃食管反流病的临床疗效.方法:符合纳入标准、诊断标准及不符合排除标准的胃食管反流病患者120例,按1∶1随机分为两组;治疗组予旋复代赭汤合左金丸颗粒剂干预4wk,对照组予兰索拉唑胶囊干预4wk.观察分析患者胸痛、胸骨后烧灼感等症状及胃镜变化.结果:治疗前,两组患者基线资料分析,无统计学差异,具有可比性;予不同药物干预4wk,胸痛、胸骨后烧灼感及内镜下食管糜烂积分均呈下降趋势,两组患者治疗前、后胃镜积分比较无统计学差异;两组治疗后胸痛,胸骨后烧灼感均明显好转(均P<0.05).其中治疗组总有效率为90.00%,对照组总有效率为86.66%,两组总体疗效比较无统计学差异.结论:旋复代赭汤合左金丸具有明确改善内镜下食管糜烂,缓解胸痛、胸骨后烧灼感等症状,疗效与兰索拉唑相似,值得临床推广应用.

AIM： To investigate the efficacy of Xuanfudaizhe Decoction in combination with Zuojin Pill in the treatment of gastroesophageal reflux disease （GERD）. METHODS： One hundred and twenty patients with GERD were randomly and equally divided into two groups： intervention group and control group. The intervention group was treated with Xuanfudaizhe Decoction in combination with Zuojin Pill for 4 wk, while the control group was treated with lansoprazole for the same duration. The clinical and endoscopic manifestations of esophageal mucosal lesions in these patients were then observed. RESULTS： Before treatment, there is no significant difference in baseline data between the two groups. After treatment for 4 wk, the scores of chest pain and heart-burn and endoscopic manifestations of esophageal mucosal erosion declined in both groups. No significant difference was observed in the total response rate between the intervention group and control group （90% vs 86.66%, P 0.05）. CONCLUSION： Xuanfudaizhe Decoction in combination with Zuojin Pill has comparable efficacy to lansoprazole in the treatment of GERD.