新疆地区成年人心房颤动的流行病学现状及相关危险因素分析

Prevalence and relative risk factors of atrial fibrillation in Xinjiang adult population

目的 了解新疆地区成年人目前心房颤动（房颤）的流行病学现状及相关危险因素.方法 应用4阶段整群随机抽样法,在全疆23个市、7个地区、5个自治州抽取年龄在35岁以上样本,男女均衡.统计不同民族组、不同年龄组、不同性别组人群的房颤患病率,并对房颤相关危险因素进行分析.结果 共抽取35岁以上城市及农村游牧居民14618人,房颤患病率为0.40%,标准化率为0.35%,其中汉族为0.31%,维吾尔族为0.25%,哈萨克族为0.59%.男性患病率高于女性（0.53%对0.28%,P＜0.05）.年龄分组显示患病率有随年龄增加的趋势.所有房颤患者中瓣膜型、非瓣膜型及孤立性房颤所占比例分别31%、36%和33%.多因素Logistic回归分析结果显示,年龄、瓣膜病、心力衰竭与房颤患病率的OR值分别为1.09、1.90、10.65.结论 新疆地区成年人房颤患病率接近于国内外有关研究结果,民族间差异无统计学意义,随年龄增加呈增多趋势;年龄、瓣膜病、心力衰竭是房颤发生的独立危险因素.

Objective To investigate the current prevalence of atrial fibrillation（AF） in Xinjiang adult population and contribute to further studies on AF in future. Methods By means of four-stage selected random sampling, adults aged over 35 years old were surveyed to analyze the prevalence and relative risk factors in different nationality,age and sex. The sampled adults were collected from 23 municipalities,7 localities and 5 autonomous counties in Xinjiang, accounted for half of male and female. Results A total of 14618 adults were surveyed. The prevalence of AF was 0. 40%, age-adjusted prevalence was 0. 35%. The prevalence of AF was 0. 31% ,0. 25% and 0. 59% in Han,Uygur and Kazak population respectively after age-adjustment. The prevalence was higher in men than in women（0. 53% vs 0. 28% ,P 〈0. 05）. The risk of AF increased substantially with aging. Among all the AF cases,valvular AF,nonvalvular AF,alone AF were accounted for 31% ,36% ,and 33% ,respectively. Multi-factor logistic analysis showed that the OR value between AF and age, heart valvular disease,chronic heart failure was 1.09、1.90 and 10. 65 respectively. Conclusion The prevalence of AF in Xinjiang adult population is similar to the whole nation of China and other countries and there is no difference between nationality. The independent risk factors of atrial fibrillation are age ,heart valvular disease and chronic heart failure.