乳腺癌新辅助化疗病人生活质量状况及其相关因素分析

Analysis of quality of life and the related factors in breast cancer patients undergoing neoadjuvant chemotherapy

目的 调查乳腺癌新辅助化疗病人的生活质量状况及其相关因素.方法 应用自设问卷及SF-36健康状况量表对88例乳腺癌病人在新辅助化疗结束后1周内的化疗副反应及其生活质量状况进行调查.结果 本组乳腺癌病人完成新辅助化疗后的SF-36各维度得分中,生理机能（72.90±23.55）分、生理职能（28.98 ±37.31）分、躯体疼痛（71.50±21.91）分、一般健康状况（53.67±21.72）分、精力（61.19±28.39）分、社会功能（61.08±28.39）分、情感职能（52.27±43.71）分共7个维度得分均低于国内正常人群（P＜0.01）.多元逐步回归分析显示,化疗副反应的数量、厌食、疲乏、年龄、文化程度对于生活质量有影响（P＜0.05）.结论 新辅助化疗后本组乳腺癌病人的生活质量降低,化疗副反应中的厌食、疲乏等是导致本组病人生活质量降低的主要因素,同时年龄越大的病人生理机能越差,而文化程度越高的病人社会功能越差.

Objective To explore the life quality of breast cancer patients received neoadjuvant chemotherapy and analyze the related factors. Methods 88 breast cancer patients were investigated in this study. To observe the adverse reaction and life quality of patients 1 week after neoadjuvant chemotherapy with self-resetting questionnaire and SF-36. Results The scores of PF（ 72. 90 ± 23. 55 ） , RP（28.98±37.31）, BP （71.50±21.91）, GH（53.67 ±21.72） ,VT（61.19 ±28.39）, SF（61.08 ±28.39）, RE（52.27 ±43.71） in SF-36 were less than domestic normal people after neoadjuvant chemotherapy （ P ＜ 0. 01 ）. Multiple stepwise regression showed the numbers of chemotherapy adverse reactions, anorexia, fatigue, age, education level have effects on life quality. Conclusions The life quality of this 88 breast cancer patients decreased after neoadjuvant chemotherapy. anorexia and fatigue in adverse reactions were the main factors affecting life quality in these breast cancer patients. The elder patients had worse physical function and the patients with high education level had worse social function.