DTPA双酰胺杂环钆(Ⅲ)配合物的合成、表征与弛豫效能

Synthesis,Characterization and Relaxivity of DTPA Double Alkyl Esters Heterocyclic Gadolinium(Ⅲ) Complexes

通过二乙三胺五乙酸(DTPA)酸酐与一种新型杂环化合物的酰化反应,得到了双酰胺共价键链接、杂环化合物修饰的DTPA配体。再与GdCl3·6H2O反应得到相应的顺磁性钆(Ⅲ)配合物。通过元素分析、FTIR、1H NMR等手段表征了配体和金属配合物的结构,进而测定了配合物的纵向弛豫率(R1)。结果表明,配合物分子稳定性很好,且在同等含钆量条件下,这种新型钆(Ⅲ)金属配合物的R1(5.12mmol·L-1·s-1)高于临床应用的磁共振成像对比剂Gd-DTPA(3.64mmol·L-1·s-1)。

The DTPA ligand modified by heterocyclic compound and linked through double alkyl ester covalent bond was synthesized by acylation reaction between diethylenetriamine pentaacetic（DTPA） bisanhydride and a novel heterocyclic compound.The corresponding paramagnetic Gd（Ⅲ） complex was gained by the reaction of the DTPA ligand with GdCl3·6H2O.The structure of the ligand and its Gd（Ⅲ） complex was characterized by elemental analysis,FTIR and 1H NMR,and the longitudinal relaxivity（R1） was measured.Besides,the magnetic resonance imaging of the new Gd（Ⅲ） complex in vitro was studied.The result suggested that the stability of the complex was well,and when the Gd（Ⅲ） quantity was identical,the R1 of the Gd（Ⅲ） complex（5.12mmol·L-1·s-1）was higher than the clinical magnetic resonance imaging contrast agent Gd-DTPA（3.64mmol·L-1· s-1）.