新鲜狼毒大戟根化学成分研究

Study on the Chemical Constituents from Fresh Roots of Euphorbia fischeriana

目的:研究新鲜狼毒大戟根的化学成分。方法:利用硅胶柱色谱进行分离纯化,通过波谱性质鉴定化合物的结构。结果:分离得到14个化合物,分别鉴定为:2,4-二羟基-6-甲氧基-3-甲基苯乙酮(1)、12-deoxyphorbol-13-hexadecanoate(2)、没食子酸乙酯(3)、七叶内酯(4)、2,4-二羟基-6-甲氧基乙酰苯(5)、12-deoxyphorbol-13-acetate(prostratin)(6)、12-deoxyphorbol-13,20-diacetete(7)、jolkinolide B(8)、17-hydroxyjolkinolide B(9)、17-hydroxyjolkinol-ide A(10)、langduin C(11)、3-甲氧基对羟基苯甲酸(12)、没食子酸甲酯(13)、β-谷甾醇(14)。结论:化合物3、5、12、13为首次从狼毒大戟中分离得到。

Objective：To study the chemical constituents in ethyl acetate fraction from the Euphorbia fischeriana.Methods：The compounds were isolated by silica gel column chromatography and HPLC,and their structures were elucidated by means of spectral analyses.Results：Fourteen compounds were identified as 2,4-dihydroxy-6-methoxy-3-methylacetophenone（1）,12-deoxyphorbol-13-hexadecanoate（2）,ethylgallate（3）,esculetin（4）,2,4-dihydroxy-6-methoxy-acetophenone（5）,12-deoxyphorbol-13-acetate（6）,12-deoxyphorbol-13,20-diacetete（7）,jolkinolide B（8）,17-hydroxyjolkinolide B（9）,17-hydroxy-jolkinolide A（10）,langduin C（11）,3-methylp-hydroxybenzoic acid（12）,methyl gallate（13）,3,3′-diacetyl-pyridine-4,4′-dimethoxy-2,2′,6,6′-tetrahydroxydiphenylmethane（14）.Conclusion：Compounds 3,5,12,13 are isolated from this plant for the first time.