摘要
目的:研究新鲜狼毒大戟根的化学成分。方法:利用硅胶柱色谱进行分离纯化,通过波谱性质鉴定化合物的结构。结果:分离得到14个化合物,分别鉴定为:2,4-二羟基-6-甲氧基-3-甲基苯乙酮(1)、12-deoxyphorbol-13-hexadecanoate(2)、没食子酸乙酯(3)、七叶内酯(4)、2,4-二羟基-6-甲氧基乙酰苯(5)、12-deoxyphorbol-13-acetate(prostratin)(6)、12-deoxyphorbol-13,20-diacetete(7)、jolkinolide B(8)、17-hydroxyjolkinolide B(9)、17-hydroxyjolkinol-ide A(10)、langduin C(11)、3-甲氧基对羟基苯甲酸(12)、没食子酸甲酯(13)、β-谷甾醇(14)。结论:化合物3、5、12、13为首次从狼毒大戟中分离得到。
Objective:To study the chemical constituents in ethyl acetate fraction from the Euphorbia fischeriana.Methods:The compounds were isolated by silica gel column chromatography and HPLC,and their structures were elucidated by means of spectral analyses.Results:Fourteen compounds were identified as 2,4-dihydroxy-6-methoxy-3-methylacetophenone(1),12-deoxyphorbol-13-hexadecanoate(2),ethylgallate(3),esculetin(4),2,4-dihydroxy-6-methoxy-acetophenone(5),12-deoxyphorbol-13-acetate(6),12-deoxyphorbol-13,20-diacetete(7),jolkinolide B(8),17-hydroxyjolkinolide B(9),17-hydroxy-jolkinolide A(10),langduin C(11),3-methylp-hydroxybenzoic acid(12),methyl gallate(13),3,3′-diacetyl-pyridine-4,4′-dimethoxy-2,2′,6,6′-tetrahydroxydiphenylmethane(14).Conclusion:Compounds 3,5,12,13 are isolated from this plant for the first time.
出处
《中药材》
CAS
CSCD
北大核心
2010年第9期1406-1409,共4页
Journal of Chinese Medicinal Materials
基金
黑龙江省留学归国人员基金项目(LC2009C02)
关键词
狼毒大戟
化学成分
Euphorbia fischeriana Steud.
Chemical constituents