摘要
The synthesis of a new series of 3-（5-substituted benzimidazol-2-yl）-5-arylisoxazolines （6a-h） was achieved in excellent yields by the condensation of 1-（1H-benzimidazol-2-yl）-3-（substituted phenyl）prop-2-en-l-ones （5a-h） with hydroxylamine at room temperature. These 1-（1H-benzimidazol-2-yl）-3-（subsfituted phenyl）prop-2-en-l-ones （Sa-h） were obtained by the condensation of 2-acetyl benzimidazoles （4a-d） with different aromatic aldehydes, which in turn were obtained by the oxidation of 2-（α- hydroxy）ethyl benzimidazoles （3a-d） prepared by the reaction of o-phenylenediamines （lad） with ot-hydroxy propiohic acid 2. The synthesized compounds were characterized by their IR, ^1H NMR and MS analyses. These compounds were screened for their antibacterial and antifungal activity by standard methods and found some of them active.
The synthesis of a new series of 3-（5-substituted benzimidazol-2-yl）-5-arylisoxazolines （6a-h） was achieved in excellent yields by the condensation of 1-（1H-benzimidazol-2-yl）-3-（substituted phenyl）prop-2-en-l-ones （5a-h） with hydroxylamine at room temperature. These 1-（1H-benzimidazol-2-yl）-3-（subsfituted phenyl）prop-2-en-l-ones （Sa-h） were obtained by the condensation of 2-acetyl benzimidazoles （4a-d） with different aromatic aldehydes, which in turn were obtained by the oxidation of 2-（α- hydroxy）ethyl benzimidazoles （3a-d） prepared by the reaction of o-phenylenediamines （lad） with ot-hydroxy propiohic acid 2. The synthesized compounds were characterized by their IR, ^1H NMR and MS analyses. These compounds were screened for their antibacterial and antifungal activity by standard methods and found some of them active.
