摘要
A facile approach for the first synthesis of ocimarin, naturally occurring coumarins, was developed by employing a cerium （III） chloride heptahydrate-catalyzed Pechmann condensation of phenols and β-keto esters in a solvent-free system as key step, by which ocimarin was achieved by three steps starting from acetylacetic ether and resorcinol with total yield 23.2%. All structures of new compounds were confirmed by IR, ^1H NMR and MS.
A facile approach for the first synthesis of ocimarin, naturally occurring coumarins, was developed by employing a cerium （III） chloride heptahydrate-catalyzed Pechmann condensation of phenols and β-keto esters in a solvent-free system as key step, by which ocimarin was achieved by three steps starting from acetylacetic ether and resorcinol with total yield 23.2%. All structures of new compounds were confirmed by IR, ^1H NMR and MS.
基金
financially supported by the National Natural Science Foundation of China(Nos. 0562010,20962016)
Ministry of National Education(No.203143)
Program for New Century Excellent Talents in University
