老年抑郁症患者舍曲林治疗前后血清细胞因子水平的研究

Sertraline reduces serum IL-6 and NTF-α in elderly depressed patient

目的 现测老年抑郁症患者使用舍曲林治疗前后血清细胞因子水平的变化.方法 采用酶联免疫吸附法（ELISA）检测30例首发老年抑郁症患者（患者组）治疗前后和30例健康老年人（对照组）的血清IL-6、TNF-α的水平并比较,并结合汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）总分及各因子分进行相关分析.结果 患者组治疗前血清IL-6：（64.35±16.27）ng/L、TNF-a：（28.26±14.57）ng/L水平显著高于正常对照组IL-6：（30.81±10.71）ng/L,TNF-α：（17.74±10.18）ng/L（P＜0.05）.舍曲林治疗后血清IL-6、TNF-α水平较治疗前显著下降（P＜0.05）.结论 血清IL-6、TNF-α水平升高可能是老年抑郁症的免疫学标志之一;舍曲林抗抑郁的同时降低血清IL-6、TNF-a水平.

Objective To explore changes of serum cytokine level in elderly depressed patient at pre- and post-treatment of Sertraline. Methods The serum eytokine level was measured by enzymatic -linked immunosorbent assay（ELISA） in case-control study including 30 first-episode elderly depressed patients and 30 healthy controls, and the association between the serum cytokine level and HAMD total score, HAMA total score or the factor score was explored. Results There is significant higher in the level of serum IL-6（64.35±16.27）ng/1,TNF-α（28.26±14.57）ng/1 in elderly patients with depression than those in ＂controls[ IL- 6 ： （30.81±10. 71 ） ng/1, TNF-α： （ 17. 74 ±10. 18） ng/1]. Serum IL-6, TNF-α level in post-treatment with Sertraline is significant lower than pre-treatment in depression （P 〈 0.05）. Conclusions The increases in the level of serum IL-6,TNF-α may be immunological markers of depression in late life; Sertraline may affect the level of serum IL-6 ,TNF-α.