微量元素与阿尔茨海默病

Trace elements and Alzheimer＇s disease

微量元素可参与酶促反应、激素及维生素的合成与转化，构成体内重要载体及电子传递系统，发挥广泛的生理效应。神经退行性疾病的发病与微量元素不平衡或代谢紊乱密切相关，本文着重介绍微量元素在阿尔茨海默病发生、发展中的重要作用，为预防和治疗提供新的思路。

There has been steadily growing evidence in the participation of trace elements in multiple physiological and biochemical processes, such as consisting of active enzyme, synthesis of hormone and vitamin, electron transportation. Additionally, Alzheimer＇s disease is characterized by disturbance of trace elements in the brain. This review summarizes studies which implicate a role for trace elements in contributing to AD, especially in the aspect of neuronal metabolism, oxidative stress, Ab deposition, and synaptic transmission.