HIV感染与心血管疾病危险因子的研究进展

Progress of research on HIV infection and risk factors to cardiovascular disease

高效抗反转录病毒治疗(Highly active antiretroviral therapy,HAART)使艾滋病(HIV/AIDS)病人的预期寿命延长,但是其引起代谢综合征的不良反应,使病人增加了罹患心血管疾病(CVD)的危险。然而近年来的研究发现,中断HAART治疗并没有降低此风险,未进行HAART治疗的艾滋病病毒(HIV)感染者也存在心血管病高发因素。文章通过对近年来HIV感染引起的病人血脂异常、免疫功能缺陷、炎症反应及血栓相关因子激活、血管损伤几个方面的文献的综述,分析单纯HIV感染对病人易患CVD的作用机制。

Highly active antiretroviral therapy（HAART） extended the life expectancy of AIDS patients,but the side effect of causing metabolic syndrome increased the risk to cardiovascular disease（CVD）.However,studies in recent years have found,interruption of HAART treatment does not reduce this risk,and a high incidence of cardiovascular disease is also reported in antiretroviral-naive HIV patients.In order to analyze the mechanism of susceptibility of HIV patients to CVD,this paper reviews the recent literature in the light of lipid abnormalities,immune dysfunction,inflammation and thrombosis-related factors activation and vascular injury.