中药难溶性药物注射给药配方策略

Formulation Strategy for Injection Administration of Poorly Water-soluble Drug in Traditional Chinese Medicine

目的:为中药难溶性药物注射给药配方提供参考。方法:根据对中药难溶性成分的特点及中药注射剂的剂型特点的分析,结合各类增溶技术的特点和规律,制定其配方策略。结果:对各类配方手段进行了系统总结,并给出了简要配方策略。结论:需加快研究符合中药及中药注射剂特点的难溶性药物配方体系。

This work explored the formulation strategy for the injectable administration of insoluble TCM. A formulation strategy was presented based on the characteristics of poorly water-soluble TCM drugs and injections, the characteristic and rule of various solubilizition techniques, as well as a systematic summary of various formulation methods. It was also proposed to strengthened the study on the formulation system of poorly water-soluble drugs, which is consistent with the features of TCM and its injectable preparations.