中药治疗类风湿性关节炎、痛风及骨性关节炎用药规律研究

The Medication Regularity of Traditional Chinese Medicine Against Rheumatoid Arthritis,Gout and Osteoarthritis

本研究以中国生物医学文献数据库为载体,类风湿性关节炎、痛风及骨性关节炎为研究对象,采用数学和统计的方法,获取高频率、协同出现的关键药对,探寻中医治疗这3种疾病的用药规律。结果显示,当归、黄芪、桂枝、芍药等为中药治疗类风湿性关节炎核心药物。牛膝、茯苓、黄柏、大黄等为治疗痛风核心药物。当归、独活、牛膝、白芍等为治疗骨性关节炎核心药。分析结果可知中医在治疗类风湿性关节炎、痛风及骨性关节炎时,大都采用活血化瘀的治疗方法。此外,在治疗类风湿性关节炎和骨性关节炎时多采用祛风湿法,在治疗痛风时多采用利水湿法。

In this research, we select Chinese BioMedical Literature Database as vector to analyze the Chinese herb medication regularity of rheumatoid arthritis, gout and osteoarthritis. The high frequency and synergism herbs pattern are obtained. The results show that The key herbs of traditional Chinese medicine treatment of rheumatoid arthritis are Dang Gui （Radix Angelica）, Huang Qi （Astragalus membranaceus （Fisch.）Bunge）, Gui Zhi （Rhizomapinelliae）, Shao Yao （Radix paeoniae alba）and so on. The key herbs of traditional Chinese medicine treatment of gout are Niu Xi （Achyranthes biden- tata）, Fu Ling （Wolfiporia cocos）, Huang Bai （Phellodendron amurense Rupr. ）, Dai Huang （Rhizoma et Radix Rhei） and so on. The key herbs of traditional Chinese medicine treatment of osteoarthritis are Dang Gui （Radix Angelica）, Du Huo （Radix angelicae biseratae ）, Niu Xi （Achyranthes bidentata）, Bai Sao （Radix paeoniae alba）. The results suggest that the TCM treatment of rheumatoid arthritis, gout and osteoarthritis usually use the treatment of promoting blood circulation. In addition, the therapy method of Dispelling Wind-wet usually used in treating rheumatoid arthritis and osteoarthritis, the therapy method of promoting urination usually used in treating gout.