期刊文献+

伯基特淋巴瘤发病机制及靶向治疗

Pathogenesis and targeted therapy of Burkitt's lymphoma
原文传递
导出
摘要 伯基特淋巴瘤(BL)是非霍奇金淋巴瘤的一种,为成熟B淋巴细胞恶性肿瘤,具有高侵袭性和增殖性。治疗中通常有明显药物不良反应,且治疗后复发率较高。随着对BL的分子水平发病机制、药物治疗及耐药等的深入研究,其疗效将有望得到提高。 Burkitt's lymphoma is a highly aggressive and proliferative type of mature B cell non- Hodgkin's lymphorna. Therapeutic strategies for Burkitt's lymphoma remain a challenge because of significant toxicities and poor prognosis. Further studies investigating the underlying molecular mechanisms of the carcino- genesis, chemotherapy and drug resistance are needed to improve the treatment of Burkitt's lymphoma.
出处 《国际肿瘤学杂志》 CAS 2010年第10期786-789,共4页 Journal of International Oncology
基金 基金项目:浙江省自然科学基金资助项目(Y207058) 浙江省重大科技专项重点社会发展项目(2009C13018)
关键词 伯基特淋巴瘤 细胞凋亡 信号传导 抗药性 Burkitt lymphoma Apoptosis Signal transduction Drug resistance
  • 相关文献

参考文献29

  • 1Jaffe ES.The 2008 WHO classification of lymphomas:implications for clinical practice and translational research.Hematology Am Soc Hematol Educ Program,2009:523-531.
  • 2Yustein JT,Dang CV.Biology and treatment of Burkitt' lymphoma.Curr Opin Hematol,2007,14(4):375-381.
  • 3Campanero MR.Mechanisms involved in Burkitt's lymphoma tumor formation.Clin Transl Oncol,2008,10(5):250-255.
  • 4Hemann MT,Bric A,Teruya-Feldstein J,et al.Evasion of the p53tumor surveillance network by tumour-derived myc mutants.Nature,2005,436(7052):807 -811.
  • 5Scheller H,Tobollik S,Kutzera A,et al.C-myc overexpression promotes a germinal center-like program in burkitt's lymphoma.Oncogene,2010,29(6):888-897.
  • 6Sanchez-Beato M,Sánchez-Aguilera A,Piris MA.Cell cycle deregulation in B-cell lymphomas.Blood,2003,101(4):1220-1235.
  • 7Wang H,Mannava S,Grachtchouk V,et al.C-myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle.Oncogene,2008,27(13):1905-1915.
  • 8Lambert SL,Martinez OM.Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10.J Immunol,2007,179(12):8225-8234.
  • 9Shore AM,White PC,Hui RC,et al.Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A.J Virol,2006,80(22):11191-11199.
  • 10Faumont N,Le Clorennec C,Teira P,et al.Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway.Cancer Res,2009,69(12):5177-5185.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部