脑钠肽、和肽素检测对冠脉病变程度的预测价值研究

Predictive value of brain natriuretic peptide and copeptin levels in detecting coronary artery disease

目的:探讨冠心病患者脑钠肽、和肽素与冠脉病变程度之间的关系。方法:入选急性心肌梗死患者(AMI组)40例、不稳定型心绞痛患者(UAP)36例、稳定型心绞痛患者(SAP组)51例和健康对照者30例,比较各组患者脑钠肽、和肽素水平与冠脉病变支数、冠脉Gensini评分相关性。结果:AMI组、UAP组脑钠肽、和肽素水平显著高于SAP组和对照组,且AMI组明显高于UAP组,差异均有统计学意义(P<0.05)。脑钠肽、和肽素水平与冠脉病变支数、左主干病变程度、冠脉Gensini评分呈正相关(P<0.05)。结论:脑钠肽、和肽素水平可反映冠心病患者临床症状与冠脉病变的严重程度。

Objective： To study the relationship between brain natriuretic peptide （BNP）, copeptin levels and the degree of coronary artery disease （CAD） in patients with CAD. Method： 40 patients with acute myocardial infarction （AMI）, 36 patients with unstable angina pectoris （UAP）, 51 patients with stable angina pectoris （SAP） and 30 cases of healthy controls were selected. The correlations of the number of impaired coronary arteries （CA）, left main coronary stenosis and Gensini scores of CA with levels of BNP and Copeptin were compared. Results： BNP and copeptin levels of AMI, UAP group were significantly higher than that of SAP and control group. BNP and copeptin levels of AMI were significantly higher than that of UAP group, the differences were statistically significant （P 〈0.05）. BNP, copeptin levels and coronary lesion vessels, left main coronary stenosis, coronary Gensini score were positively correlated （P 〈0.05）. Conclusion： BNP and copeptin levels reflect the severity of clinical symptoms and impaired coronary arteries of CAD patients.