急性肾功能损伤早期生物标志物的研究现状与临床应用

Assessment of biomarkers in early diagnosis and prediction of acute kidney injury

急性肾功能损伤(Acute kidney injury,AKI)是临床常见病,它的早期发现一直是肾脏病学非常棘手的问题,同时也是急症医学、检验医学及其他相关学科迫切需要解决的问题。尽管近年来人们在急性肾功能损伤的治疗方法上取得了很大的进步,但其发病率和死亡率并未明显下降。导致这种状况的原因,一方面与对AKI的认识不足有关,另一方面,急性肾功能损伤早期生物标志物的缺乏是更主要原因。因此,寻找能早期能诊断和预测AKI的生物标志物就显得尤为重要。本文主要就近年来评估AKI生物标志物的研究现状与临床应用进展作一论述。

Acute kidney injury is a commonly encountered disease. It＇s early detection is a tough problem on Nephrology, analysis medicine, critical care medicine and other relevant subject. Notwithstanding for the past few years people have got much progress in the therapies of the acute kidney injury, it＇s morbidity and mortality don＇t obviously descend.The cause of this condition is that people haven＇t completely know the acute kidney injury and the deficiency on the prophase biomarker of the acute kidney injury. For this reason, looking for the prophase biomarker of the acute kidney injury become more and more important. The article will discuss the study current situation and clinical application of biomarker of the acute kidney injury.