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MACC1与结肠癌的研究进展 被引量：6

Progress of research on MACC1 in colon cancer
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摘要 MACC1(metastasis-associated in coloncancer1)是最近被报道的一种在结肠癌中调控肿瘤生长和转移的重要基因。MACC1作为诱导肿瘤转移发生的HGF/Met信号旁路的调控者,有可能作为肿瘤的早期阶段预测是否发生远处转移的一个生物学指标。MACC1可能成为结肠癌预后评估及进行个体化治疗方案制定的指标,可能成为肿瘤基因治疗的重要靶点。因此,研究MACC1与结肠癌的关系在对于肿瘤的防治有其重要的意义。本文结合国内外文献就MACC1在结肠癌发生发展及其转移过程的研究进展作一综述。 MACC1（metastasis-associated in colon cancer1）, an important regulator of tumor growth and metastasis has recently been identified in colon cancer. MACC1 acts as a key regulator of the metastasis-inducing HGF/Met pathway, predicts the risk for metastasis in early cancer stages. MACC1 may play an important role for metastasis prediction and individual treatment planning. MACC1 may be an important therapeutic target for colon cancer treatment. So it is significant to study the relationship between MACC1 and colon cancer for tulnor prevention and treatment. In combination with domestic and overseas literatures, this article provides a brief review of the research progress in the roles of MACC1 in the genesis, development and metastasis of colon cancer.
作者 章国星 操寄望
机构地区 武汉大学人民医院消化内科
出处 《现代生物医学进展》 CAS 2010年第19期3792-3794,共3页 Progress in Modern Biomedicine
关键词 MACC1 结肠癌 转移 MACC1； colon cancer； Metastasis；
分类号 R735.35 [医药卫生—肿瘤]
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参考文献26

  • 1Parkin DM, Bray F, Ferlay J, Pisani P, et al. Global cancer statistics, 2002 [J]. CA Cancer J Clin ,2005, 55(2): 74-108.
  • 2O'Connell JB, Maggard MA, Ko CY, et al. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging [J]. J Natl Cancer Inst ,2004,96(19):1420-5.
  • 3Ulrike Stein, Wolfgang Walther, Franziska Arlt, et al. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis [J]. Nat Med ,2009a,15(1):59-67.
  • 4Kokoszy n ska K, Kryn ski J, Rychlewski L, et al. Unexpected domain composition of MACC1 links MET signaling and apoptosis [J]. Acta Biochim Pol,2009,56(2):317-23.
  • 5Zhang J, Xu LG, Hart KJ, et al. Identification of a ZU5 and death domain-containing inhibitor ofNF-kap-paB[J]. J Biol Chem ,2004,279 (17): 17819-17825.
  • 6Sikorski AF, Hanus-Lorenz B, Jezierski A,et al. Interaction:of membrane skeletal proteins with membrane lipid domain [J]. Acta Biochim Polon, 2000, 47(3): 565-578.
  • 7Ipsaro J J, Huang L, Mondragon A. Structures of the spectrin-ankyrin interaction binding domains [J]. Blood ,2009,113(22): 5385-5393.
  • 8Ulrike Stein, Mathias Dahlmann, Wolfgang Walther. MACC1 - more than metastasis ? Facts and predictions about a novel gene [J]. J Mol Med ,2010,88(1): 11-18.
  • 9Reed JC, Doctor KS, Godzik A .The domains of apoptosis: a genomics perspective [J]. Sci STKE, 2004,2004(239):re9.
  • 10Ranziska Arlta, Ulrike Stein. Colon cancer metastasis: MACC1 and Met as metastatic pacemakers [J]. The International Journal of Biochemistry & Cell Biology ,2009,41 (12):2356-2359.

二级参考文献15

  • 1Webb CP, Taylor GA, Jeffers M, Fiscella M, Oskarsson M,Resau JH, Vande Woude GF. Evidence for a role of met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene 1998;17:2019-2025.
  • 2Parr C, Watkins G, Mansel RE, Jiang WG. The hepatocyte growth factor regulatory factors in human breast cancer. Clin Cancer Res 2004;10(1 Pt 1):202-11.
  • 3Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophysiol Res Comm 1984;122:1450-1459.
  • 4Vila MR, Nakamura T, Real F. Hepatocyte growth factor is a potent mitogen for normal human pancreas cells in vitro. Lab Invest 1995;73:409-418.
  • 5Rosen EM, Meromsky L, Setter E, Vinter DW, Goldberg ID.Purified scatter factor stimulates epithelial and vascular endothelial cell migration. Proc Soc Exp Biol Med 1990;195:34-43.
  • 6Brinkmann V, Foroutan H, Sachs M, Weidner KM, Birchmeier W.Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J Cell Biol 1995;131:1573-1586.
  • 7Zhang YW, Vande Woude GF. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J Cell Biochem 2003;88:408-417.
  • 8Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE,Vande Woude GF, Aaronson SA. Identification of the hepatocyte growth factor as the c-met proto-oncogene product. Science 1991;251:802-804.
  • 9Amemiya H, Kono K, Itakura J, Tang RF, Takahashi A, An FQ, Kamei S, lizuka H, Fujii H, Matsumoto Y. c-Met expression in gastric cancer with liver metastasis. Oncology 2002:63:286-296.
  • 10La Rosa S, Uccella S, Capella C, Erba S, Sessa F. Localization of hepatocyte growth factor and its receptor met in endocrine cells, and related tumors of the Gut and Pancreas : An immunohistochemical study. Endocr Pathol 2000:11:315-329.

共引文献12

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二级引证文献20

现代生物医学进展
2010年 第19期

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