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白细胞介素12:重要的免疫调节因子 被引量:4

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摘要 IL-12是由巨噬细胞和B细胞产生的一种异二聚体细胞团子,具有多种生物学活性的免疫效应细胞生长刺激因子。能显著增强NK/LAK细胞的杀伤活性,促进特异性CTL细胞的应答能力,诱导γ干扰素,它不仅对细胞免疫具有增强调节作用,且可与其它细胞因子协同作用,有可能成为重要的免疫治疗细胞因子。
出处 《国外医学(临床生物化学与检验学分册)》 1999年第3期118-119,134,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
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  • 1Jihed Chehimi,Giorgio Trinchieri. Interleukin-12: A bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency[J] 1994,Journal of Clinical Immunology(3):149~161

同被引文献28

  • 1徐进梅,吴海玮,吴观陵.血吸虫病肝纤维化中细胞因子的网络作用[J].国外医学(寄生虫病分册),2004,31(4):150-154. 被引量:11
  • 2高锐,辛宇鹏,卢一平,王佳,李幼平.不同免疫抑制剂对大鼠血管平滑肌细胞转化生长因子-β1和Smads信号通路的影响及意义[J].中华实验外科杂志,2006,23(8):965-967. 被引量:4
  • 3Johnson J, Reid M. Anticoccodoal drugs lesion scoring techniques in battery and floor pen experiments with chickens[J]. Exp Parasit, 1970, 28: 30-36.
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  • 7韩森,高慧,李卫芬.4种抗球虫药防制鸡艾美耳球虫的试验[J].饲料研究,2007,30(9):18-19. 被引量:5
  • 8Hendrzak J A, Brunda M J. Interleukin-12, biologic activity,therapeutic utility, and role in disease. Lab Invest, 1995, 72:619.
  • 9Orange J S, Brion C A. Characterization of early IL-12, IFNα, β and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol, 1996,156:4746.
  • 10Farah I O, Mola P W, King C L et al. Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-β and IL-4. J Immunol, 2004, 164:5337.

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