他克莫司与抗真菌药物的联合抗真菌作用与机制

Antifungal effect and mechanism of tacrolimus combined with antifungal agents

侵袭性真菌感染越来越受到关注,特别是耐药真菌感染的治疗已成为困扰临床的棘手问题。非抗真菌药物与抗真菌药物的联合应用是研究热点之一。本文综述非抗真菌药物他克莫司与常用抗真菌药物联合对多种耐药及敏感的念珠菌、隐球菌、曲霉菌、须疮癣菌及马拉色菌的联合抗真菌作用与分子机制。研究表明,协同作用的分子基础与真菌细胞中存在钙调蛋白磷酸酶和受体结合蛋白有关,但不同菌属机制不尽相同。

More attention has been paid to the invasive fungal infection,especially to the resistant fungal infection.Drug combination between non-antifungal and antifungal drugs is one of those hot topics.This article focuses on reviewing the combined antifungal effects and the synergistic molecular mechanisms of the non-antifungal drug tacrolimus and antifungal agents against sensitive or resistance fungi of Candida,Aspergillus,Cryptococcus,Mentagrophytes and Malassezia species.The results reveal that the basis of the combined antifungal effect could relate to calcineurin and FKBFs,but synergistic molecular mechanism is not all the same for different species.