急性脑梗死NSE变化与胰岛素抵抗的相关性研究

Study on relationship between insulin resistance and neuron specific enolase in the patients of acute cerebral infarction

[目的]探讨急性脑梗死患者神经元特异性烯醇化酶(NSE)的变化情况;急性脑梗死NSE异常者是否存在胰岛素抵抗;急性脑梗死患者NSE与胰岛素敏感指数(ISI)是否存在直线相关关系。[方法]选取急性脑梗死患者75例,对照组55例。急性脑梗死组依据NSE测定结果,分为NSE异常组(39例)和NSE正常对照组(36例)。各组分别检测空腹血糖、空腹血清胰岛素、NSE,计算体重指数、胰岛素敏感指数、胰岛素抵抗指数(HOMA-IR)。[结果](1)急性脑梗死组NSE明显高于对照组,差异有非常显著性意义,P<0.01;(2)在急性脑梗死NSE异常组中FPG、FINS、HOMA-IR高于NSE正常组,差异有显著性意义,P<0.05;ISI明显低于NSE正常组,P为0.0085,差异有非常显著性意义,P<0.01;(3)急性脑梗死组NSE与ISI直线相关分析显示,急性脑梗死患者NSE与ISI呈显著负相关(r=-0.524,P<0.01)。[结论]急性脑梗死患者NSE明显增高;NSE异常者存在IR;急性脑梗死患者NSE与胰岛素敏感性呈负相关。

【Objective】 To investigate the relationship between insulin resistance（IR） and neuron specific enolase（NSE） in the patients of acute cerebral infarction.【Methods】 Seventy-five patients diagnosed with acute cerebral infarction were divided into NSE abnormal group（39 cases） and NSE normal group（36 cases） according to their NSE levels,and another 55 healthy physical examinees were chosen as the control group.Their fasting plasma glucose（FPG）,fasting plasma insulin（FINS） and NSE levels were detected simultaneously,and the body mass index（BMI）,insulin sensitivity index（ISI）,insulin resistance index（HOMA-IR） were calculated.【Results】（1）The NSE in the patients of acute cerebral infarction were significantly higher than that in the control group,P〈0.01;（2）The FPG,FINS and HOMA-IR in NSE abnormal group were higher than that in NSE normal group,P〈0.05,whereas the ISI in NSE abnormal group was significantly lower than that in NSE normal group,P〈0.01;3.ISI was negatively correlated with NSE（r=-0.524,P〈0.01）.【Conclusion】 The ISI was negatively correlated with the NSE level in the patients of acute cerebral infarction.