CXC趋化因子受体2与肿瘤血管形成

CXC chemokine receptor 2 and tumor angiogenesis

CXC趋化因子受体2(CXC chemokine receptor 2,CXCR2)属于趋化因子受体的一种,为7次跨膜G蛋白偶联受体,主要表达于中性粒细胞、巨噬细胞、血管内皮细胞和肿瘤细胞等细胞表面。CXCR2与其配体结合后,参与机体的多种病理生理过程,包括炎症、感染、创伤愈合和肿瘤发生等过程,其在恶性肿瘤演进中所起的作用是多方面的,它通过直接促进肿瘤生长、转移以及通过促进肿瘤血管形成、白细胞浸润,共同促进了肿瘤的发生发展。近年来,CXCR2在肿瘤血管生成中的作用日益受到重视。CXCR2在不久的将来有望成为抗肿瘤的一个新的靶点。

CXC chemokine receptor 2 is a member of the chemokine receptors,which possesses seven hydrophobic transmembrane domains and expresses on the surface of neutrophils,macrophages,endothelial cells,tumor cells,etc.When CXCR2 binds with its ligands,it will play a role in many patho-physiological conditions,including inflammation,infection,wound healing,and tumorigenesis.The role of CXCR2 in malignant tumors is complex：CXCR2 may participate in tumor growth and metastasis by promoting tumor cell proliferation,migration,angiogenesis or neutrophil infiltration in tumor tissue.In recent years,with the development of tumor-related studies,CXCR2 in the role of tumor angiogenesis have received increasing attention,CXCR2 in the near future may become a new anti-cancer target.