复方肠泰联合FOLFOX4方案治疗大肠癌的临床观察

Clinical observation of Fufangchangtai decoction combined with FOLFOX 4 regimen for postoperative colorectal cancer

目的观察中药复方肠泰联合FOLFOX 4方案治疗大肠癌根治术后患者的疗效及毒副反应。方法将30例符合入选标准的大肠癌根治术后患者分为治疗组和对照组。对照组仅应用FOLFOX 4方案全身化疗,治疗组在化疗同时服用复方肠泰水煎剂。FOLFOX 4方案:奥沙利铂(OXA)85mg/m2静滴2h,第1、2天;亚叶酸钙(CF)200mg/m2静滴2h,第1、2天;氟尿嘧啶(5-FU)400mg/m2静脉推注,第1、2天,600mg/m2持续静滴22h,第1、2天。复方肠泰每日1剂,早晚各1次水煎服。14天为1周期。2个周期结束后评价疗效及毒副反应。结果 30例患者全部完成治疗。经中医证候评定,治疗组和对照组的显效+有效率分别为86.6%和53.3%(P<0.01);治疗组治疗前后Karnofsky评分未见统计学差异,对照组则降低(P<0.01);治疗组治疗后较治疗前QOL评分提高(P<0.05),对照组未见明显改变;治疗组治疗后较治疗前CD3+、CD4+升高(P<0.05),对照组未见明显改变。治疗组的白细胞减少发生率低于对照组(P<0.05),两组血小板减少、消化道反应、肝肾功能毒性及神经毒性无显著差异。结论中药复方肠泰联合FOLFOX 4方案治疗大肠癌能够有效提高患者体力状况,改善中医证候、生活质量及免疫状态,降低白细胞减少发生率,起到减毒增效作用。

Objective To observe the therapeutic effect of FOLFOX 4 regimen plus Fufangchangtai decoction on postoperative colorectal cancer.Methods Thirty postoperative colorectal cancer patients were allocated into control and experiment group respectively.Patients in experiment group were given Fufangchangtai decoction combined with FOLFOX 4 regimen.Patients in control group were given FOLFOX 4 regimen alone.Efficacy was evaluated after 2 periods of treatment.Results The improvement rate of symptoms was 86.6% in experiment group compared to 53.3% in control group.KPS was stable in experiment group,and decreased in control group.QOL was increased in experiment group,and stable in control group after the treatment.For impact of immunity parameters,there was an enhancement of CD3＋ and CD4＋ in experiment group,while they did not change in the control group.In experiment group,WBC reduction was slighter than that of control group.The differences were not remarkable in PLT reduction,alimentary response,and toxity of liver and kidney and nervous system.Conclusion The clinical observation shows that Fufangchangtai decoction plus FOLFOX 4 regimen could effectively enhance KPS,improve the symptoms,the quality of life and the immunity state,and down-regulate the side effects.All in all,it can decrease the toxity so as to enhance the treatment effect.