miR-17-92基因簇与肿瘤

mir-17-92 Cluster and Tumor——Review

微小RNA(miRNA)是近年来新发现的与肿瘤的发生发展密切相关的一类RNA。它可通过调控其靶标基因参与的信号通路,影响肿瘤的发生和发展,发挥着类似于癌基因或抑癌基因的功能,因此miRNA失调在肿瘤中起重要作用。较多的研究发现,miR-17-92簇与肿瘤的发生密切相关,具有癌基因和抑癌基因双重功能。本文就miR-17-92簇在肿瘤中的作用机制及功能作一综述。

MicroRNA（miRNA） is a class of RNA which has been discovered in recent years and relates with genesis and development of tumors.MiRNA affects the genesis and development of tumors and carries out the function similar to oncogene and antioncogene through regulation of signaling pathway in which target genes involved,thereby the miRNA disregulation plays an important role in oncogenesis.More studies revealed that the miR-17-19 cluster closely correlates with tumorigenesis and has bifunctional effects of oncogene and antioncogene.In this review,the mechanism and function of the miR-17-19 cluster in tumorigenesis are summarized.