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狼疮性肾炎患者外周血调节性T细胞变化的意义 被引量：3

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摘要 目的:探讨活动期和静止期狼疮性肾炎(LN)患者外周血中调节性T细胞CD4+CD25+CD127lo(Treg)变化的意义。方法:流式蛋白分析系统(CBA)测定外周血IL-6、IL-10水平,流式细胞仪测定外周血CD19+CD69+、CD19+凋亡率、Tregs水平。结果:(1)①LN患者CD19+CD69+、CD19+凋亡率水平较正常组升高(P<0.01);②活动期LN CD4+、CD4+CD25+CD127lo水平较正常组降低(P<0.01);静止期CD4+、CD4+CD25+CD127lo与正常组比较差异无统计学意义;③活动期LN患者IL-10、IL-6、CD19+CD69+、CD19+凋亡率水平较静止期显著升高(P<0.01)。(2)Treg与CD19+CD69+、CD19+凋亡率无相关性,与IL-10、IL-6呈负相关(P<0.05),与ds-DNA、SLEDAI呈负相关(P<0.01)。CD19+凋亡率与IL-10呈负相关(P<0.01),与SLEDAI、CD19+CD69+呈正相关(P<0.01)。结论:Treg可作为狼疮活动性的指标,并能够减少或完全抑制自身抗体的产生。
作者 郑京 薛原 吴宽裕 江敏 陈雪兰 王菊霞 陈小丽 刘芳 郑春盛 冯木兰 林善忠
机构地区 福建省人民医院 福建医科大学附属第一医院 福建省第二人民医院
出处 《中国中西医结合肾病杂志》 2010年第9期821-823,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 福建省自然基金资助项目(No.2009j01162)
关键词 狼疮性肾炎 B淋巴细胞凋亡率 调节性T细胞 白细胞介素-6 白细胞介素-10
分类号 R593.242 [医药卫生—内科学]
  • 相关文献

参考文献8

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二级参考文献13

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共引文献8

同被引文献24

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引证文献3

二级引证文献5

中国中西医结合肾病杂志
2010年 第9期

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