GP和NP方案对老年非小细胞肺癌化疗后贫血的影响

Impact of GP and NP Chemotherapy on Anemia in Elderly NSCLC Patients

目的探讨GP和NP方案在老年非小细胞肺癌化疗过程中对贫血的影响。方法对2002年1月—2007年1月的5年中接受GP或NP方案治疗的患者中采用配对设计方法各随机抽取30例,化疗后第一、二、四周分别检测Hb,RBC、HCT及铁代谢指标。结果两组病例一周后均出现Hb,RBC、HCT及sFn下降,第二周下降最明显,第四周各项指标有所回升。结论采用GP和NP方案对老年非小细胞肺癌患者化疗可产生贫血,但在调整化疗用药量及化疗间隔时间后,贫血程度在患者耐受范围内。

Objective To investigate the effect of GP and NP chemotherapy on anemia to elderly NSCLC patients.Method Sixty patients were selected in the past five years,and divided into GP and NP group randomly.Hb,RBC,HCT and iron metabolism of all cases and were detected at the first,second and fourth week.Result The Hb,RBC,HCT and sFn of all the patients in two groups descended after one week.At the second week,all the indexes were the lowest,while in the fourth week each index recovered.Conclusion To elderly NSCLC patients,GP and NP chemotherapy resulted into anemia,however,which was tolerant through dose and interval regulation.