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活性氧在细菌耐抗生素机制中的作用 被引量：3

Role of reactive oxygen species in mechanisms of antimicrobial resistance in bacteria
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摘要 细菌对抗生素的耐药性以惊人的速度蔓延,阐明抗生素导致细菌死亡内在机制,对提高抗生素药效以及寻找新型抗生素显得尤为迫切。近期研究表明,抗生素引起的细菌内活性氧物质(reactive oxygen species,ROS)产生,是导致细菌细胞死亡的关键原因。该文对ROS、SOS和细菌耐药性方面的最新研究进行了综述和探讨,为开发新型抗菌药物,遏制细菌感染和耐药性提供新的思路。 Antibiotic resistance has been spreading at an alarming rate among pathogens,which poses a great threat to human health.It is critical to investigate the mechanisms of action of antibiotics in order to develop new antibiotics and enhance the efficacy of the existing ones.Recent studies indicate bactericidal antibiotics kill pathogens via a common pathway involving reactive oxygen species（ROS）.In this review,the recent progress in the interplay of ROS,SOS and antibiotic resistance has been discussed.These data should prove to be of importance for the development of new antibiotic strategies and encountering with pathogen drug resistance.
作者 张亚妮 段康民
机构地区 西北大学生命科学学院
出处 《中国药理学通报》 CAS CSCD 北大核心 2010年第9期1129-1131,共3页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30870097) 2010年陕西省自然科学基金资助项目(No2010JQ4023) 2010年陕西省教育厅科学研究项目
关键词 抗生素 耐药性 活性氧 SOS 损伤负荷 损伤修复 antibiotic drug resistance reactive oxygen species SOS lesion burden repair damage
分类号 R-05 [医药卫生] R378 [医药卫生—病原生物学]
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参考文献28

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共引文献6

同被引文献46

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引证文献3

二级引证文献25

中国药理学通报
2010年 第9期

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