慢性乙型肝炎气分证和血分证的血清病毒学标志物分析

The relationship between serum hepatitis B virus markers and traditional Chinese medicine type of syndrome

目的探讨慢性乙型肝炎中医证型与血清病毒学标志物的关系。方法对299例慢性乙型病毒性肝炎患者行中医辨证诊断,同时检查血清病毒学标志物,按气分证和血分证分组。结果血分证组的HBeAg阴性率显著高于气分证组(P<0.01),血分证组的HBVDNA对数值显著低于气分证组(P<0.05),两组的HBVDNA阳性率无显著性差异。结论血分证患者的乙型肝炎病毒发生基因变异率比较高,血分证的病因病机与乙型肝炎病毒基因变异可能存在着某种互为因果的关系。

Objective To investigate the correlation between the serum hepatitis B virus markers and traditional Chinese medicine（TCM） type of syndrome in chronic hepatitis B patients.Methods 299 patients were divided into two groups based on the classical differential diagnosis in traditional Chinese medicine： Syndrome of qi system and syndrome of xue system.The serum hepatitis B virus markers were detected.Results HBeAg negativity rate was significantly higher in pa-tients with syndrome of xue system than syndrome of qi system（P 0.01）.The serum HBV DNA level in patients with syndrome of xue system was significantly lower than syndrome of qi system（P 0.05）.There was no significant difference in HBV DNA positivity rate between the two groups.Conclusion Hepatitis B virus mutation was higher in patients with syndrome of xue system than syndrome of qi system.These mutations are probably related to syndrome of xue system.