乌司他丁联合法舒地尔治疗蛛网膜下腔出血的疗效评价

Effects of ulinastatin combining with fasudil on subarachnoid hemorrhage

目的:探讨乌司他丁联合法舒地尔治疗蛛网膜下腔出血的临床意义。方法:60例蛛网膜下腔出血患者随机分为两组,每组30例,联合组(A组)在常规治疗基础上给予乌司他丁联合法舒地尔治疗,法舒地尔组(B组)在常规治疗基础上给予法舒地尔治疗,分别于发病后3、5、7d采用放射免疫法测定血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平,比较两组的治疗效果。结果:联合组血清TNF-α、IL-6、IL-8水平在发病后3、5、7d时间点均较法舒地尔组低(P<0.05);发病后10d联合组神经功能评分(GCS评分)较法舒地尔组显著增高(P<0.05)。结论:乌司他丁联合法舒地尔治疗蛛网膜下腔出血疗效显著,可以降低蛛网膜下腔出血早期血清TNF-α、IL-6、IL-8的水平,有利于神经功能的恢复和改善预后。

Objective：To evaluate the efficacy of ulinastatin combining with fasudil on the subarachnoid hemorrhage.Methods：A total of 60 patients with subarachnoid hemorrhage were randomly divided into ulinastatin combining with fasudil group（group A）and fasudil group（group B）by half.Based on routine therapy,group A was also given ulinastatin combining with fasudil,while group B was only given fasudil.Therapeutic effects of the two groups were evaluated and compared ,5,and 7 days after onset by detecting serum TNF-а,IL-6 and IL-8 levels with radioimmunoassay method.GCS were also determined in all the patients within 12 hours and 10 days of onset.Results：The serum TNF-а,IL-6 and IL-8 levels were all significantly lower in group A than that in group B ,5 and 7 days after onset（P〈0.05）.GCS were significantly higher in group A than that in group B 10 days after onset（P〈0.05）.Conclusion：Combination of ulinastatin and fasudil can improve the prognosis of subarachnoid hemorrhage patients by reducing serum TNF-а IL-6 and IL-8 levels as well as improving nervous function.