安冲汤止血调经的临床观察及机理研究

Clinical Observation and Mechanism Study on Stopping Bleeding and Regulating Menses with Anchong Decoction

目的探讨以益气固冲、止血调经立法的安冲汤治疗月经过多、经期延长的疗效及作用机理。方法将60例脾肾气虚型月经过多、经期延长患者随机分为两组,治疗组30例,服安冲汤治疗;对照组30例,服益宫宁血口服液治疗。观察两组病例治疗前后临床症状、卵泡刺激素(FSH)、促黄体生成激素(LH)、雌二醇(E2)、孕酮(P)、子宫内膜雌激素受体(ER)、孕激素受体(PR)、子宫内膜生长因子(EGF)、血管内皮生长因子(VEGF)、血PGI2的代谢产物6-keto-PGF1α/血栓素TXA2的代谢产物TXB2的改善情况。结果治疗组总有效率为86.7%,对照组总有效率为63.3%,两组比较,差异有统计学意义(P<0.05)。治疗后治疗组FSH、EGF、VEGF升高,ER、PR显著降低,与对照组比较,差异有统计学意义(P<0.05或P<0.01)。结论安冲汤止血调经具有良好的疗效,可能通过促进子宫内膜血管生长,促进创面修复而止血。

Objective：To explore the efficacy and mechanism of anchong decoction on profuse menstrual flow and prolonged menstruation based on the treatment principle as benefiting qi,consolidating the Conception Vessel,stopping bleeding and regulating menses.Methods：60 cases of profuse menstrual flow and prolonged menstruation due to spleen and kidney qi deficiency were randomized into two groups.In treatment group（30 cases）,anchong decoction was administered.In control group（30 cases）,yigong ningxue oral liquid was administered.The improvements in clinical symptoms,follicle stimulating hormone（FSH）,luteotropic hormone（LH）,estrogen（E2）,progesterone（P）,estrogen receptor（ER）,progesterone receptor（PR）,endometrial growth factor（EGF）,vascular endothelial growth factor（VEGF）and 6-keto-PGF1（metabolite of PGI2）/TXB2（metabolite of TXA2）were observed before and after treatment in two groups.Results：The total effective rate was 86.7% in treatment group and was 63.3% in control group,indicating statistical significant difference in comparison（P0.01）.After treatment,in treatment group,FSH,EGF and VEGF increased,and ER and PR decreased significantly,indicating statistical significant difference as compared with control group（P0.05 or P0.01）.Conclusion：Anchong decoction is well effective on stopping bleeding and regulating menses and it cures profuse menstrual flow through promoting the growth of uterine endometrial vessel and wound healing.