5Gladstone DE,Peyster R,Baron E,et al.High-dose Cyclophosphamide for Moderate to Severe Refractory Multiple Sclerosis:2-Year-Follow-up(Investigational New Drug No.65863)[J].Am J Ther,2009,14(1):1-8.
1Sellebjerg F,Barnes D,Filippini G,et al.EFNS guideline on treatment of multiple sclerosis relapses:report of an EFNS task force on treatment of multiple sclerosis relapses[J].Eur J Neurol,2005,12(12):939-946.
2Cho IJ,Kim SG.A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor(GR)interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR[J].Mol Endocrinol,2009,23(1):86-99.
3Charmandari E,Kino T,Ichijo T,et al.Functional characterization of the natural human glucocorticoid receptor(hGR)mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance[J].J Clin Endocrinol Metab,2006,91(4):1535-1543.
4Charmandari E,Kino T,Ichijo T,et al.A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance[J].J Clin Endocrinol Metab,2007,92(10):3986-3990.
5Raef H,Baitei EY,Zou M,et al.Genotype-phenotype correlation in a family with primary cortisol resistance:possible modulating effect of the ER22/23EK polymorphism[J].Eur J Endocrinol,2008,158(4):577-582.
6van Winsen LM,Hooper-van Veen T,van Rossum EF,et al.Glucocorticoid receptor gene polymorphisms associated with more aggressive disease phenotype in MS[J].J Neuroimmunol,2007,186(1/2):150-155.
7van Winsen LM,Manenschijn L,van Rossum EF,et al.A glucocorticoid receptor gene haplotype(TthIII1/ER22/23EK/9beta)is associated with a more aggressive disease course in multiple sclerosis[J].J Clin Endocrinol Metab,2009,94(6):2110-2114.
8Charmandari E,Chrousos GP,Ichijo T,et al.The human glucocorticoid receptor(hGR)beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes[J].Mol Endocrinol,2005,19(1):52-64.
9Goleva E,Li LB,Eves PT,et al.Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma[J].Am J Respir Crit Care Med,2006,173(6):607-616.
10Kelly A,Bowen H,Jee YK,et al.The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases[J].J Allergy Clin Immunol,2008,121(1):203-208.
