急性冠状动脉综合征患者血浆妊娠相关蛋白酶A与脂联素、瘦素含量变化的关系

Relationship of serum pregnancy-associated plasma protein A and adiponectin or leptin level in patients with acute coronary syndrome

目的探讨急性冠状动脉综合征患者血浆妊娠相关蛋白酶A(PAPP-A)与脂联素、瘦素含量变化及其在急性冠状动脉综合征发生过程中的意义。方法 80例急性冠状动脉综合征患者(A组)采用酶联免疫吸附测定法检测血浆PAPP-A、脂联素和瘦素含量,并与45例稳定型心绞痛患者(B组)和40例健康体检者(C组)进行比较。结果 A组血清脂联素含量显著低于B组与C组,(7.61±2.32)mg/L vs(10.36±2.28)mg/L、(14.32±3.24)mg/L(P<0.01),B组血清脂联素含量低于C组(P<0.01)。A组血清瘦素含量高于B组与C组,(20.14±3.13)μg/L vs(13.36±2.32)μg/L、(9.23±2.44)μg/L(P<0.01),B组血清瘦素含量高于C组(P<0.01)。A组PAPP-A水平明显高于B组与C组,(17.62±8.72)mU/L vs(11.21±3.75)mU/L、(8.31±5.21)mU/L(P<0.01),B组PAPP-A水平高于C组(P<0.01);急性冠状动脉综合征患者血浆PAPP-A与脂联素、瘦素含量之间存在相关性。结论 PAPP-A、脂联素和瘦素在急性冠状动脉综合症发病机制中发挥重要作用,PAPP-A与脂联素、瘦素含量之间存在相关性。

Objective To investigate the change of serum pregnancy-associated plasma protein A（PAPP-A） and adiponectin or leptin level in patients with acute coronary syndrome（ACS） and its possible relationship with ACS pathogenesis.Methods The plasma concentrations of PAPP-A and adiponectin or leptin level were measured with ELISA in 80 patients with ACS（A group）,45 patients with stable angina pectoris（B group） and 40 normal subjects in control group （C group）.Results Serum PAPP-A and leptin concentrations in A group were higher than those in B group,（17.62±8.72） mU/L,（20.14±3.13） μg/L vs（11.21±3.75） mU/L,（13.36±2.32） μg/L and C group（8.31±5.21） mU/L,（9.23±2.44） μg/L（P0.01）,which in B group they were higher than those in C group,（11.21±3.75） mU/L,（13.36±2.32） μg/L vs（8.31±5.21） mU/L,（9.23±2.44） μg/L（P0.01）.Serum adiponectin concentrations in A group were lower than those in B group and C group,（7.61±2.32） mg/L vs（10.36±2.28） mg/L,（14.32±3.24） mg/L（P0.01）,which in B group they were lower than those in C group,（10.36±2.28） mg/L vs（14.32±3.24） mg/L（P0.01）.There was correlation between serum PAPP-A and adiponectin or leptin level in patients with ACS.Conclusion PAPP-A and adiponectin or leptin play an important role in the pathogenesis of ACS and there was correlation between them.