成年人急性淋巴细胞白血病方案优化与分层治疗

Optimizing and stratification therapy for adult acute lymphoblastic leukemia

儿童急性淋巴细胞白血病（AML）疗效在不断改善，而成年人ALL疗效一直没有大的改观。临床上很多危险因素影响其预后，其中最重要的是早期对治疗的反应。儿童ALL的方案与成年人方案相比采用了更大剂量的左旋门冬酰胺酶、激素和长春碱，采用儿童方案可以改善成年人ALL的预后。对于Ph^＋ALL、CD20^＋ ALL联合靶向治疗有助于提高患者长期生存。异基因造血干细胞移植仅适用于高危、复发难治性ALL。

Unlike children, the outcome of adult acute lymphoblastic leukemia （ALL） has not changed in past decades. There are many risk factors influencing the outcome. The most important factor is the early response to chemotherapy. The outcome of adult ALL is improved when receiving pediatric ALL regimen. Targeting therapy combined with chemotherapy have improved the outcome of Ph~ ALL and ALL expressing CD20 Allogeneic stem cell transplantation is beneficial to high risk ALL.