结节性淋巴细胞为主型霍奇金淋巴瘤七例

7 cases of nodular lymphocyte-predominant Hodgkin lymphoma

目的探讨结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）临床病理特征及治疗。方法经病理免疫组织化学证实为NLPHL患者7例。6例患者接受化疗和受累野放疗的综合治疗；1例仅接受单纯化疗。结果3年局部控制率和总生存率分别为100％和86％。1例患者死于化疗后肺部感染。结论NLPHL预后良好，综合治疗耐受好，不良反应少，但应注意治疗后不良反应的处理。

Objective To investigate the clinicopathological characteristics and treatment of nodular lymphocyte-predominant Hodgkin lymphoma （N.LPHL）. Methods Seven patients were confirmed as NLPHL by pathologic immunohistoehemistry. Six patients received combined-modality therapy of chemotherapy and involved field, and the other one received single chemotherapy. Results The 3-year local control rate and overall survival rate were 100 % and 86 %, respectively. Only one case died of pulmonary infection following chemotherapy. Conclusion These patients with NLPHL has favorable prognosis, tolerance and less toxicity for combined-modality therapy. However the management of toxicity following treatment should be noted.