MMP-2、MMP-14在乳腺癌中的表达及临床意义

The Expression of MMP - 2 and MMP - 14 in breast cancer and its clinical significance

目的 探讨基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶-14（MMP-14）在乳腺良性病变、乳腺癌中的表达及其与肿瘤大小、分化程度、腋窝淋巴结转移的关系.方法 应用免疫组织化学PV二步法检测68例乳腺癌组织和24例乳腺良性病变组织中MMP-2和MMP-14蛋白表达情况,并分析其与临床病理参数的关系.结果 MMP-2和MMP-14在乳腺癌中阳性表达率分别为55.9%（38/68）、58.8%（40/68）,在乳腺良性病变中的阳性表达率分别为25.0%（6/24）、16.7%（4/24）,差异均有统计学意义（P＜0.05）;MMP-2和MMP-14的表达与肿瘤大小和腋窝淋巴结转移呈正相关.结论 MMP-2 和MMP-14的表达与肿瘤大小、乳腺癌淋巴结转移有关,可作为评估乳腺癌浸润和转移的生物学指标.

Objective To investigate the relation between the expression of matrix metalloproteinase 2 （MMP- 2） ,matrix metalloproteinase 14（ MMP - 14 ）in breast cancer and tumor size, differentiation and lymph node metastases. Methods Sixtyeight cases of breast cancer and twentyfour cases of breast benign disease were studied by PV hnmunohistochemieal staining with anti MMP - 2, MMP - 14 monoclonal antibodies. Results 1. The expression rates of MMP - 2 and MMP - 14 were 55.9 % （38/68 ） and 58.8 % （40/68） in breast cancers respectively,they were 25.0% （6/24） and 16.7% （4/24） respectively in breast benign disease. The expression rates were significantly higher than those in breast benign disease （ P 〈 0.05 ） ; 2. Expression of MMP - 2 and MMP - 14 in breast cancers were positive correlated with axillary lymph node methstases and tumor size （ P 〈 0.05 ）. Conclusion The expression of MMP - 2 and MMP - 14 closely correlated to lymph node metastasis and tumor size, they can act as prognostic markers of invasion and metastasis for patients with breast cancer.