期刊文献+

新生儿缺氧缺血性脑病血浆一氧化氮一氧化氮合成酶水平及临床意义 被引量:3

下载PDF
导出
摘要 探讨新生儿缺氧缺血性脑病(HIE)时一氧化氮(NO)、一氧化氦合成酶(NOS)的变化及意义。方法采用比色等方法测定32例HIE及30例正常新生儿血浆NO、NOS活性水平。结果HIE急性期NO、NOS水平较正常新生儿明显升高(P<0.05),中、重度HIE升高更显著(P<0.01),中、重度HIE患儿NO、NOS较轻度HIE患儿明显升高。结论NO、NOS水平高低与HIE患儿脑损伤程度和预后有关,可作为判断HIE患儿病情恢复及预后的指标之一。
出处 《实用儿科临床杂志》 CAS CSCD 1999年第3期140-141,共2页 Journal of Applied Clinical Pediatrics
  • 相关文献

共引文献4

同被引文献32

  • 1周军平,魏根福,严彭钧,张奇亮,魏振成,冯志徐,于兰庆.新生儿缺氧缺血性脑病血浆与脑脊液内皮素变化及临床意义[J].临床儿科杂志,1997,15(1):19-20. 被引量:4
  • 2Volpe JJ. Perinatal brain injury: from pathogenesis to neuroprotection [J ]. Ment Retard Dev Disabil Res Rev, 2001,7 ( 1 ) :56 - 64.
  • 3Compagnoni G, Pogliani L, Lista G, et al. Hypothermia reduces neurological damage in asphyxiated newborn infants [J ]. Biol Neonate,2002,82(4) :222 - 722.
  • 4Battin MR, Dezoete JA, Gunn TR, et al. Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia [ J ]. Pediatrics, 2001,107 (3) :480 - 484.
  • 5Zhu C,Wang X,Hagberg H, et al. Correlation between caspase- 3 activation and three different markers of DNA damage in neonatal cerebral hypoxia - ischemia [ J ]. J Neurochem, 2000,75 ( 2 ): 819 - 829.
  • 6Beckman JS. Oxidative damage and tyrosine nitration from peroxynitrite [J ]. Chem Res Toxicol, 1996,9(5) :836 - 844.
  • 7Ferriero DM, Holtzman DM, Black SM, et al. Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxicischemic injury [ J ]. Neurobiol Dis, 1996,3 ( 1 ): 64 - 71.
  • 8Karabiyikoglu M, Han HS, Yenari MA, et al. Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variatios depending on timing of cooling [J ].J Neurosurg,2003,98(6): 1271 - 1276.
  • 9Eguchi Y, Yamashita K, Iwamoto T, et al. Effects of brain temperature oncalmodulin and microtubule - associated protein 2 immunoreactivity in the gerbil hippocampus following transient forebrain ischemia [J ]. J Neurotrauma, 1997,14 (2) :109 - 118.
  • 10Blomgren K, McRae A, Bona E, et al. Degradation of fodrin and MAP - 2 after neonatal cerebral hypoxic - ischemia [J]. Brain Res,1995,684(2): 136 - 142.

引证文献3

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部