噬菌体及其内溶素的应用研究进展

Advances in research and development of phage and phage-encoding lysins

抗生素的滥用使越来越多的病原菌产生抗药性,因此寻求新的抗菌素已经变得极为迫切。噬菌体以及噬菌体编码的内溶素的发现和应用,为耐药性细菌的治疗和预防开辟了新的途径。文章综述了近几年噬菌体和内溶素的研究进展及其应用。

With the widespread resistance to antibiotics among pathogenic bacteria,it is particularly urgent to develop new antibiotic alternatives.Extensive studies have shown that phage and phage-encoded lytic enzymes（virolysins） were two of the most promising alternative antibacterials for the treatment and prophylaxis of bacterial infections.This review was focused on the recent advance of research and development and related applications in phage and lysins.