人脑胶质瘤微血管数与病理级别及预后关系的初步研究

A study on relationship between microvessel quantity and histological grade and prognosis in glioma.

目的探讨人脑胶质瘤微血管数（ＭＶＱ）与病理级别、术后复发、生存期及患者年龄、性别、肿瘤生长部位的关系。方法应用免疫组织化学ＡＢＣ法检测６３例人脑胶质瘤组织中Ⅷ因子相关抗原（ＦⅧＲＡｇ）的表达，计数ＭＶＱ。结果高恶性度（Ⅲ、Ⅳ级）胶质瘤ＭＶＱ高于低恶性度（Ⅰ、Ⅱ级）胶质瘤（Ｐ＜０．０５）。术后１８个月内复发及生存期小于３年者ＭＶＱ均明显高于对应组（Ｐ均＜０．０１）。ＭＶＱ与患者性别、年龄及肿瘤生长部位无关。结论人脑胶质瘤ＭＶＱ与病理级别、术后复发及生存期关系密切。

Objective To research the relationship among microvessel quantity (MVQ), age, sex, tumor position, histological grade, postoperative recurrence and survival period in glioma.Methods Using ABC immunohistochemistry method, the expression of factor Ⅷ related antigen (FⅧRAg) and MVQ were observed in 63 cases of glioma.Results MVQ in high malignant (grade Ⅲ,Ⅳ) glioma was higher than that in low malignant (grade Ⅰ,Ⅱ) glioma ( P<0.05 ). MVQ in tumor tissues of the patients in whom tumors recurred in 18 postoperative months and survival periods were less than 3 years was significantly higher than that of counterparts ( P<0.01 ). MVQ was not correlated to patient age, sex and tumor location.Conclusions MVQ was obviously correlated to histological grade, postoperative recurrence and survial period in glioma, MVQ may be an independent prognostic indicator.