重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白治疗类风湿关节炎的疗效与安全性观察
摘要
类风湿关节炎（rheumatoid arthritis,RA）是一种以慢性破坏性关节炎为特征的全身性自身免疫病,抗原驱动和T细胞淋巴介导的B细胞淋巴活化以及炎症因子的释放导致滑膜破坏是RA的主要发病机制和病理改变。滑膜中被抗原激活的T淋巴细胞引起血管和滑膜细胞增殖形成血管翳,引起关节肿痛,继而软骨破坏、关节间隙变窄,晚期关节畸形、功能障碍，最终导致不同程度的残疾。
出处
《中国药物与临床》
CAS
2010年第11期1274-1277,共4页
Chinese Remedies & Clinics
参考文献12
-
1O'Dell JR,Haire CE,Erikson N,et al.Treatment of rheumatoid arthritis with methotrexate alone,sulfasalazine and hydroxychloroquine,or a combination of all three medications.N Engl J Med,1996,334(20):1287-1291.
-
2Kent Kwoh C.Guidelines for the management of rheumatoid arthritis.Arthritis Rheum,1996,39(5):713-721.
-
3Raza K,Buck Iey CE,Salmon M,et al.Treating very early rheumatoid arthritis.Best Pract Res Clin Rheumatol,2006,20(5):849-863.
-
4Amett FC,Edworthy SM,Bloch DA,et al.The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.Arthritis Rheum,1988,31(3):315-324.
-
5Felson DT,Anderson JJ,Boers M,et al.American College of Rheumatolngy.Preliminary definition of improvement in rheumatoid arthritis.Arthritis Rheum,1995,38(6):727-735.
-
6Siegel SA,Shealy DJ,Nakada MT,et al.The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality/n vivo.Cytokine,1995,7(1):15-25.
-
7Goldring SR.Pathogenesis of bone and cartilage destruction in rheumatoid arthritis.Rheumatology,2003,42(Suppl 2):1-16.
-
8Firestein GS.Etiology and pathogenesis of rheumatoid arthritis//Kelley WN,Harris ED,Ruddy S.Textbook of Rheumatology.5th ed.Publisher:W B Saunders Co,2004.
-
9Klareskog L,van der Heijde D,de Jager JP,et al.Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis,double-blind randomised controlled trial.Lancet,2004,363(9410):675-681.
-
10Moreland LW,Schiff MH,B aumgartner SW,et al.Etanercept therapy in rheumatoid arthritis.Ann Intern Med,1999,130(6):478-486.
-
1田新平,于孟学.类风湿关节炎的生物治疗[J].北京医学,2005,27(8):488-492. 被引量：2
-
2栗占国.老年类风湿关节炎的治疗[J].老年医学与保健,2003,9(3):137-140. 被引量：19
-
3王国太,宁朝荣.系统性红斑狼疮肺间质病变病因探析[J].中国医学创新,2011,8(13):193-194.
-
4自身免疫性疾病、结缔组织疾病[J].国外科技资料目录（医药卫生）,2000(10):56-56.
-
5栗占国.规范类风湿关节炎的内科治疗[J].继续医学教育,2005,19(7):63-65. 被引量：1
-
6肖光华,何青青,何东仪,朱远熔.Wnt信号通路与类风湿关节炎关系的研究[J].山西医药杂志（上半月）,2012,41(12):1219-1222. 被引量：2
-
7王虹蕾.益赛普治疗强直性脊柱炎的疗效[J].中国实用医刊,2012,39(15):121-122. 被引量：2
-
8高玲,占伊扬.生物制剂和常规方法在风湿免疫病中的疗效对比观察[J].山西医药杂志,2016,45(16):1886-1888. 被引量：6
-
9曾玉.益赛普治疗风湿免疫疾病的疗效观察及护理[J].吉林医学,2011,32(7):1417-1418. 被引量：10
-
10朱发术.注射用重组人Ⅱ型肿瘤坏死因子受体—抗体融合蛋白治疗类风湿关节炎并冠心病疗效观察[J].临床合理用药杂志,2012,5(13):89-89. 被引量：1
