乳腺原发恶性淋巴瘤临床分析(附14例报告)

Primary Malignant Lymphoma of the breast(A report of 14 cases)

乳腺是粘膜相关淋巴瘤的发生部位，其原发淋巴瘤罕见。本文报导和分析了１４例乳腺原发性淋巴瘤的临床表现，形态特征和免疫表型。患者年龄范围为２６岁～６７岁，中位年龄４７岁。临床症状和体征除有乳腺肿块外．无其它特异性的阳性发现。病变部位包括左侧乳腺８例，右侧６例二组织学上均为弥漫型非何杰金氏淋巴瘤。１０个病例的免疫组化结果表明９例（９０．０％）为Ｂ细胞来源：１例（１０．０％）为Ｔ细胞来源。９个病例在组织学上可见淋巴细胞围绕残余乳腺导管浸润或导管上皮增生形成所谓淋巴上皮病变，部分瘤细胞有浆细胞样分化或瘤组织中有浆细胞浸润。提示至少部分肿瘤属粘膜相关淋巴瘤。结合文献对本病的诊断，治疗和预后作了简略地讨论。

The breast is one of the sites in which the lymphoma of the mucosa-associated lymphoid tissue occurs,however .the primary lymphomas of the breast are rare. In the paper,we analyze and report the clinical manifestions,morphological features and immunophynotypes of 14 such cases. The age Sange of the patients ranged from 26 to 67 years old,with a median age of 47. The main presenting symptom was mammary mass,without other specific findings. The involved breasts were left-sided in & cases, right-sided in 6 cases. Histologically,they were all diffuse non-Hodgkin lymphoma. The results of immunohisfo chemical study on 10cases showed that fumors 8, gcases (90. 0% )were derived from B cell and only one(10. 0% ) from T cell. In 9 cases,we found infiltration of lymphooma cells surrouding the mammary duct,proliferation of the duct epithelium to form so-called lymphoeplthelial lesions,and differentiation of tumor cells toward plasmocytes or infiltration of plasmocytes in tumor tissue, which indicating that at least some of them belongs to the lymphoma of mucosa-associated lymphoid tissue. The diagnosis, treatment and prognosis of the disease were briefly discussed.