4Manzillo G, Piccinino F, Surrenti C, et al. Multicentredouble-blind placebo-controlled study of intravenous and oral s-Adenosyl-L-Methionine (SAMe) in cholestatic pa- tients with liver disease [J]. Drug Investigation, 4 (Suppl 4), 1992:90.
5Frezza M, Surrenti C, Manzillo G, et al. Oral S-adeno- sylmethionine in the symptomatic treatment of intrahepat- ic cholestasis. A double-blind, placebo-controlled study [J]. Gastroenterology, 1990,99 ( 1 ) : 211.
6Higgins JPT, Green S (editors). Cochrane handbook for systematic reviews of interventions version5.1.0[updated March 2011 ]. The Cochrane Collaboration, 2011 [EB/OL]. httla://www.cochrane-handbook.org.2011-04-06.
