摘要
目的:研究将更昔洛韦制备成药物树脂复合物。方法:优选药物树脂复合物的制备方法,对药物树脂复合物进行红外光谱分析、差示热分析和热重分析。结果:动态交换法的优化条件为药物浓度4 mg·ml^(-1),树脂粒径为200～300目,流速1ml·min^(-1)。结论:动态交换法优于静态交换法,树脂与药物通过离子键的化学吸附结合。
Objective： To prepare the gancicloveir resins. Method： The method of drug-resin complexes preparation was opti- mized, the ganciclovir resins were analized by IR-spectrum, DSC and TG analysis. Result： The drug concentration that prepared the gancicloveir resins was 4 mg· ml - 1 and the resin particle size was 200-300 screen mesh, the efflux speed was 1 ml· min - 1. Conclusion： The column method is better than the bath method,the drug and resins combine with chemistry absorb of electrovalent bond.
出处
《中国药师》
CAS
2010年第11期1559-1562,共4页
China Pharmacist
基金
深圳市科技计划项目(2D200609180044B)
