血清果糖胺测定作为糖尿病诊断单一指标可行性的研究

Study on the feasibility of serum fructosamine as a single index for the diagnosis of diabetes

目的通过对糖尿病确诊患者(测试组)及非糖尿病患者(对照组)进行血清果糖胺水平检测,评价该指标作为糖尿病单一诊断指标的可行性。方法采用自动生化分析仪对30例糖尿病患者及30例非糖尿病患者进行空腹血糖、餐后2h血糖及果糖胺测定,比较两组患者空腹血糖、餐后血糖及果糖胺结果差异有无统计学意义。结果测试结果表明,测试组果糖胺异常率达94.3%,数值范围(2.51±0.37)mmol/L,与对照组比较差异有统计学意义(P<0.05),测试组、对照组空腹血糖及餐后2h血糖差异均有统计学意义(P<0.05)。结论开展果糖胺试验可以反映患者测定前2～3周前的平均血糖水平,可作为糖尿病诊断筛查的灵敏指标。

Objective To explore the feasibility of a single diagnosis and evaluation of serum fructosamine as the indicators of diabetes in the test group（patients with diabetes） and the control group（non diabetic patients） . Methods 30 diabetic patients and 30 controls underwent fasting blood glucose,postprandial 2hblood glucose and fructosamine determination by means of automatic biochemical analyzer,and the results were compared to see whether there were significant differences in fasting blood glucose,postprandial 2h blood glucose and fructosamine.Results The test results showed that abnormal fructosamine was occupied by 94.3% in the test group,with the range of values being（2.51±0.37） mmol/L,and compared with the control group,there were significant differences（P 0.05） .At the same time,there were significantly different in the fasting plasma glucose and 2 hpostprandial blood glucose in both the test and control groups（P〈0.05） .Conclusion The fructosamine test may be carried out to show the average blood glucose level of the patients 2or 3 weeks ago,and can be used as a sensitive index of diagnosis of diabetes screening.