血培养联合降钙素原与超敏C反应蛋白在新生儿败血症早期诊断中的应用

Discussion of the value of the application of blood culture,the serum procalcitonin and high sensitivity creactive protein in neonatal sepsis patients

目的探讨血培养联合血清降钙素原(PCT)和超敏C反应蛋白(hs-CRP)检测在诊断新生儿败血症中的应用。方法采用固相免疫色谱法和免疫比浊法分别测定新生儿败血症患儿的PCT、hs-CRP浓度,并与血培养结果比较。结果与对照组相比,败血症组患儿中PCT和hs-CRP水平明显升高,差异有统计学意义(P<0.01);败血症组患儿血培养结果与PCT结果比较差异无统计学意义(P>0.05),败血症组患儿血培养结果与hs-CRP结果比较差异有统计学意义(P<0.01)。结论 PCT与hs-CRP均可作为早期识别新生儿败血症及其严重性的重要指标,可作为血培养的重要补充指标。

Objective To evaluate the clinical significance of the detection of blood culture,serum procalcitonin（PCT） and high sensitivity C-reactive protein（hs-CRP） in the diagnosis of neonatal sepsis.Methods Solid-phase immune chromatography and immune nephelometry were used to determine the levels of serum PCT and CRP in neo-natal sepsis patients,and the test was data compared with the results of blood culture.Results The levels of PCT and CRP in the neonatal sepsis group were significantly higher than those in the controls（P〈0.01） .However,the levels of PCT compared with the results of blood culture in the neonatal sepsis group were not significant（P〉0.05） ,while the levels of hs-CRP,compared with the results of blood culture in the same group,were significant（P〈0.01） . Conclusion Both PCT and CRP are the important makers for early diagnosis of neonatal sepsis,and can make the im-portant supplement experiment of the blood culture.