冠心病、高血压患者血清同型半胱氨酸和超敏C反应蛋白的水平变化及临床意义

Analysis on the levels of Hcy and hs-CRP in the patients with coronary heart disease and hypertension

目的探讨血清同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)在冠心病和高血压患者中的检测意义。方法采用循环酶法测定血清Hcy浓度,用颗粒增强免疫透射比浊法测定hs-CRP含量。结果与对照组相比,冠心病组和冠心病合并高血压组血清hs-CRP与Hcy均显著升高,差异有统计学意义(P<0.01)。与冠心病组相比,冠心病合并高血压组血清Hcy浓度有显著升高,差异有统计学意义(P<0.01);而血清hs-CRP浓度增高不明显,差异无统计学意义(P>0.05)。结论血清hs-CRP、Hcy与冠心病及冠心病合并高血压有密切联系,其检测对冠心病的治疗有十分重要的临床价值。

Objective To explore the relationship of the serum homocysteine（Hcy）,high sensitive C-reactive protein（hs-CRP）in patients with coronary heart disease and hypertension.Methods Fluoresce-ce polarization immunoassay was applied to detect the Hcy level,and particle reinforced transmission immunoturbidimetry assay was applied to detect the concentration of hs-CRP.Results The serum Hcy and hs-CRP levels in patients with coronary heart disease and hypertension were significantly higher than that in the control group（P〈0.01）.The content of hs-CRP in patients with coronary heart disease complicated with hypertension was signifycantly higher than that in the only coronary heart disease group（P〈0.01）.While the serum Hcy was not significantly different.Conclusion The concentrations monitoring of Hcy and hs-CRP have close relationship with the coronary heart disease and hyper-tension,and the tests are important for the diagnosis of coronary heart disease.