期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

LINGO-1对CNS损伤神经元和髓鞘再生的影响 被引量：1

下载PDF
导出
摘要 Nogo受体作用蛋白（LINGO-1）是特异表达于中枢神经系统神经元和少突胶质细胞中的一类跨膜蛋白,拥有12个富含亮氨酸的重复序列（LLR）和一个免疫球蛋白结构,一个跨膜区和一个胞质内的短尾端。其主要生理作用是调节大脑的发育。
作者 戚韵雯 张圆 郭庆山
机构地区 重庆医科大学临床医学一系 第三军医大学学员旅 第三军医大学大坪医院
出处 《检验医学与临床》 CAS 2010年第21期2412-2413,共2页 Laboratory Medicine and Clinic
关键词 神经元 突胶质细胞 跨膜蛋白 中枢神经
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献4

二级参考文献48

  • 1秦峰松,杨崇林.小线虫,大发现:Caenorhabditis elegans在生命科学研究中的重要贡献[J].生命科学,2006,18(5):419-424. 被引量：30
  • 2MIYAUCHI K, KOMANO Y, OKOMAKU J, et al. Role of the specific amino acid sequence of the membranespanning domain of human immunodeficiency virus type 1 in membrane fusion[ J]. J Virol, 2005, 79:4720 - 4729,.
  • 3SHACKLETT B L, SHAW K E S, ADAMSON L A,et al. Live attenuated simian immunodeficiency virus SIVmac - M4, with point mutations in the Env transmembrane protein intracytoplasmic domain, provides partial protection from mucosal challenge with pathogenic SIVmac251 [J]. J Virol, 2002, 76(22) :11365 - 11378.
  • 4Ben-Hur T, Einstein O, Mizrachi-Kol R, et al. Transplanted multipoten tial neural precursor cells migrate into the inflamed white matter in re sponse to experimental auto immune encephalomyelitis[J]. Glia, 2003, 41 (1): 73-80.
  • 5Einstein O, Fainstein N, Vaknin I, et al. Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression [J]. Ann Neurol, 2007, 61 (3): 209-218.
  • 6Einstein O, Grigoriadis N, Mizrachi-Kol R, et al. Transplanted neural precursor ceils reduce brain inflammation to attenuate chronic experi mental auto immune encephalomyelitis[J]. Exp Neurol, 2006, 198 (2): 275-284.
  • 7Ibanez C, Shields SA, El-Etr M, et ol. Systemic progesterone adminis tration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats [J]. Neuropathol Appl Neurobiol, 2004, 30 (1): 80-89.
  • 8Kotter MR, Li WW, Zhao C, et al. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation [J]. J Neurosci, 2006, 26 (1): 328-332.
  • 9Kotter MR, Zhao C, van Rooijen N, et al. Macrophage-depletion induced impairment of experimental CNS remyelination is as soci ated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression [ J]. Neurobiol Dis, 2005, 18 ( 1 ): 166-175.
  • 10Li WW, Penderis J, Zhao C, et ol. Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS[J]. Exp Neurol, 2006, 202 (1): 250-254.

共引文献4

同被引文献13

  • 1戚其学,李玉芬,赵珊珊,聂莹雪,赵传胜.强制性运动疗法对脑缺血后神经元轴突再生及Nogo-A蛋白水平影响的研究[J].中国血液流变学杂志,2008,18(3):317-319. 被引量：9
  • 2范有明,蔡明春.Nogo-66受体RNA干扰质粒的构建及其干扰效率鉴定[J].第三军医大学学报,2007,29(13):1285-1288. 被引量：2
  • 3Lv J,Xu R X,Jiang X D,et al.Passive immunization with LINGO- 1 polyclonal antiserum afforded neuroprotection and promoted functional recovery in a rat model of spinal cord injury[J].Neuroimmunomodulation,2010,17(4) :270-278.
  • 4Vilarino-Guell C,Ross O A,Wider C,et al.LINGO1 rs9652490 is associated with essential tremor and Parkinson disease[J].Parkinsonism Relat Disord,2010,16(2) : 109-111.
  • 5Llorens F,Gil V,Iraola S,et al.Developmental analysis of Lingo-1/ Lernl protein expression in the mouse brain:interaction of its intracellular domain with Myt 11[J].Dev Neurobiol, 2007,68 (4) : 521-541.
  • 6Giger R J,Hollis E R 2nd,Tuszynski M H.Guidance molecules in axon regeneration[J].Cold Spring Harb Perspect B iol, 2010,2(7): 1-21.
  • 7Schwab J M,Tuli S K,Failli V.The Nogo receptor complex:confining molecules to molecular mechanisms[J].Trends Mol Med, 2006, 12 (7) :293-297.
  • 8Mi S,Sandrock A,Miller R H.LINGO-1 and its role in CNS repair [J].Int J Biochem Cell Biol,2008,40(10) : 1971-1978.
  • 9Chan J R,Watkins T A,Cosgaya J M,et al.NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes [J].Neuron, 2004,43(2) : 183-191.
  • 10Lee X,Yang Z,Shao Z,et al.NGF Regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination[J].J Neurosci, 2007,27( 1 ) : 220-225.

引证文献1

二级引证文献3

检验医学与临床
2010年 第21期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部