先天性唇腭裂病儿TORCH感染的血清学研究

Study on serology of congenital cleft lip and cleft palate patients TORCH infection.

目的：为了探讨弓形虫（ＴＯ），风疹病毒（ＲＶ），巨细胞病毒（ＣＭＶ）和单纯疱疹病毒Ⅱ（ＨＳＶⅡ）感染与先天性唇腭裂发生的关系。方法：对１２０例２月龄至１０岁唇腭裂病儿和６２名正常儿童血清抗ＴＯ－ＩｇＭ，抗ＲＶ－ＩｇＭ，抗ＣＭＶ－ＩｇＭ和抗ＨＳＶⅡ－ＩｇＭ用ＥＬＩＳＡ法作检。结果：病儿阳性率分别为４．２％，３．３％，３３．３％和３．３％，正常儿分别为１．６％，３．２％，２１．０％和３．３％，两者统计学上无显著差异。２～３月龄组病儿抗ＣＭＶ－ＩｇＭ阳性率为４３．８％，显著高于正常儿的９．１％（Ｐ＜０．０５）。结论：唇腭裂的发生与ＴＯ，ＲＶ和ＨＳＶⅡ感染可能无明显关系，与先天性ＣＭＶ感染有一定关系。

Objective:For the purpose of studing the relation betweet toxoplasma (TO), rubella vieua (RV), cytomegalovirus (CMV) and herpesvirusⅡ (HSVⅡ) and congenital cleft lip and clelft palate. Methods:The seruml anti-To-IgM, anti-RV-IgM, anti-CMV-IgM and anti-HSVⅡ-IgM of 120 cases of two months to 10 years old cleft lip and cleft palate patients and 62 normal children were meassured by the ELISA method. Results:The results showed that the positives rate of the patients were 4.2%, 3.3%,33.3% and 3.3% respectively, and ones of normal children were 1.6%,3.2%,21.0 and 3.2%respectively, in which there were no significant differences in the both groups, that the positive rates of anti-CMV-IgM in two months to three months old patints were 43.8%, which was significant higher than normal children (9.1%) (P<0.05) Conclusions:The results indicated that cleft lip and cleft palate may be not obvious relative to TO,RV,and HSVⅡ infection, and may be definite relative to congenital CMV infection.