睡眠呼吸紊乱和脑血管病的关系

The relationship between sleep related breathing disorders and stroke

目的了解睡眠呼吸紊乱（SRBD）与脑血管病（CVD）的关系。方法用多导睡眠图对43例CVD患者和43名性别、年龄和体块指数与CVD组匹配且神经系统正常者进行比较。结果CVD组中SBBD（以阻塞性为主）发病率明显增高，呼吸紊乱指数、血氧饱和度（SaO2）减低指数均显著大于对照组，平均和最低SaO2低于对照组，低氧血症持续时间也长于对照组。CVD组睡前、醒后和平均血压均明显高于对照组，CVD组中SRBD患者的高血压发病率也明显高于非SRBD患者，SRBD对CVD的危险性较大（OR值为6．85）。结论SRBD是CVD重要的危险因素之一，CVD也可能诱发或加重SRBD，二者形成恶性循环，影响CVD的康复。

Objective To study the relatinoship between sleep related breathing disorder(SRBD)and cerebrovascular diseases (CVD).Methods Polysomnographic studies on 43 cases of CVD were performed and 43sex-,age-,body mass index- compatible cases without CVD used as controls. Results The incidence of SRBD (mostly the obstructive one) was much more in CVD patients and bothe the obstructive and central apnea/hypopea indices, deoxygenation indices were bigger and deoxygenation time were longer while the mean and lowest oxygen saturation were lower in CVD group than those in the controls (all P<0.05).The blood pressure before sleep,after awakening and the mean BP during sleep were also higher in the CVD patients. In CVD group, the incidence of hypertension was also much highe in SRBD patients than tha in non-SRBD ones (P < 0.01). SRBD was dangerous for CVD as OR valus was 6.28. Conclusions SRBD may be one important risk fastor for CVD. An vicious circle might be formed between stroke and SRBD which inflences the outcome of stroke.